Research ArticleHIV

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

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Science Translational Medicine  30 Aug 2017:
Vol. 9, Issue 405, eaam5441
DOI: 10.1126/scitranslmed.aam5441

Curbing complications in chronic HIV

HIV-infected patients who have viral suppression due to treatment are still at enhanced risk of comorbidities such as neurological or cardiovascular complications, so Schechter et al. explored how inflammation and coagulation intersect in chronic HIV. To do so, they examined monocytes that express tissue factor in samples from patients or macaques infected with SIV. These monocytes appear to be crucial to coagulopathy. Treatment with a compound isolated from tick saliva, Ixolaris, can interrupt this damaging pathway. It is possible in the future that HIV patients would be treated with Ixolaris to stem some of the side effects of chronic infection.