Research ArticleDengue

Increased adaptive immune responses and proper feedback regulation protect against clinical dengue

See allHide authors and affiliations

Science Translational Medicine  30 Aug 2017:
Vol. 9, Issue 405, eaal5088
DOI: 10.1126/scitranslmed.aal5088

Distinguishing dengue presentation

Although dengue hemorrhagic fever can be life-threatening, not all dengue virus infections even present with symptoms. To determine what may be driving the differences in clinical and asymptomatic infections, Simon-Lorière et al. examined the serum and immune gene transcripts of Cambodian children infected with dengue virus serotype 1. They saw that relative to those with clinical infections, the small subset of asymptomatic children had increased signs of antigen presentation, T cell activation, and T cell apoptosis; plasmablast differentiation and anti-dengue antibodies seemed relatively lower. These results provide clues for pathways that may drive pathologic responses in severe dengue virus infections.