30 August 2017
Vol 9, Issue 405

About The Cover

Cover image expansion

ONLINE COVER Dengue Détente. Prevalence of dengue virus, shown here, is increasing. Some infections lead to lethal hemorrhagic fever, but many others cause no symptoms and go undetected. To try to distinguish what may cause these different responses to infection, Simon-Lorière and colleagues examined the immune responses of Cambodian children infected with serotype 1 dengue virus. In general, T cell pathways were more activated in asymptomatic cases and B cell pathways were more activated in clinical cases. These results reveal how the immune system can fight dengue virus infection without escalating the battle to the detriment of the patient. [CREDIT: VITSTUDIO/SHUTTERSTOCK]