Contents
30 August 2017
Vol 9, Issue 405
Vol 9, Issue 405
Focus
- Subcutaneous drug delivery: An evolving enterprise
Recent advances in subcutaneous drug delivery and device design are transforming the biopharmaceutical sector and improving patient care.
Research Articles
- Increased adaptive immune responses and proper feedback regulation protect against clinical dengue
Increased activation of adaptive immunity and proper feedback mechanisms can eliminate dengue viral infection without clinical symptoms.
- Rare autosomal trisomies, revealed by maternal plasma DNA sequencing, suggest increased risk of feto-placental disease
Maternal plasma cell-free DNA sequencing reveals rare autosomal trisomies that are associated with perinatal complications.
- Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis
Targeted gene delivery and enzyme inhibition in vascular and perivascular cells promote engraftment of transplanted parenchymal cells for lung and liver repair.
- Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy
Activated monocytes in blood promote chronic inflammation and persistent coagulation in HIV-infected patients and SIV-infected macaques.
Editors' Choice
- Rewriting the genome in human embryos
Researchers have edited the genome of human embryos to correct dominant myocardial disease.
- Nanotransfection brings progress that’s more than skin-deep
Arrayed nanochannels efficiently transfect skin for local in vivo genetic reprogramming.
- Deterring zoster
Germline mutations in RNA polymerase III cause susceptibility to life-threatening varicella zoster infection.
- More excitation for Rett syndrome
D-cycloserine ameliorates breathing abnormalities and survival rate in a mouse model of Rett syndrome.
About The Cover
ONLINE COVER Dengue Détente. Prevalence of dengue virus, shown here, is increasing. Some infections lead to lethal hemorrhagic fever, but many others cause no symptoms and go undetected. To try to distinguish what may cause these different responses to infection, Simon-Lorière and colleagues examined the immune responses of Cambodian children infected with serotype 1 dengue virus. In general, T cell pathways were more activated in asymptomatic cases and B cell pathways were more activated in clinical cases. These results reveal how the immune system can fight dengue virus infection without escalating the battle to the detriment of the patient. [CREDIT: VITSTUDIO/SHUTTERSTOCK]
