Research ArticleHYDROCEPHALUS
A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus
- Hannah F. Botfield1,2,*,
- Maria S. Uldall3,*,
- Connar S. J. Westgate1,2,
- James L. Mitchell1,2,4,
- Snorre M. Hagen3,
- Ana Maria Gonzalez5,
- David J. Hodson1,2,6,
- Rigmor H. Jensen3 and
- Alexandra J. Sinclair1,2,4,†
- 1Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.
- 2Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK.
- 3Danish Headache Center, Clinic of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Nordre Ringvej 69, 2600 Glostrup, Denmark.
- 4Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.
- 5Institute of Inflammation and Ageing, University of Birmingham, Edgbaston B15 2TT, UK.
- 6Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
- ↵†Corresponding author. Email: a.b.sinclair{at}bham.ac.uk
↵* These authors contributed equally to this work.
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Science Translational Medicine 23 Aug 2017:
Vol. 9, Issue 404, eaan0972
DOI: 10.1126/scitranslmed.aan0972
Vol. 9, Issue 404, eaan0972
DOI: 10.1126/scitranslmed.aan0972
Hannah F. Botfield
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK.
Maria S. Uldall
Danish Headache Center, Clinic of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Nordre Ringvej 69, 2600 Glostrup, Denmark.
Connar S. J. Westgate
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK.
James L. Mitchell
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK.Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.
Snorre M. Hagen
Danish Headache Center, Clinic of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Nordre Ringvej 69, 2600 Glostrup, Denmark.
Ana Maria Gonzalez
Institute of Inflammation and Ageing, University of Birmingham, Edgbaston B15 2TT, UK.
David J. Hodson
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK.Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
Rigmor H. Jensen
Danish Headache Center, Clinic of Neurology, Rigshospitalet-Glostrup, University of Copenhagen, Nordre Ringvej 69, 2600 Glostrup, Denmark.
Alexandra J. Sinclair
Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston B15 2TT, UK.Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK.Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.
