Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma

Haipeng Zhang; Kai Li; Yuan Lin; Fan Xing; Xiao Xiao; Jing Cai; Wenbo Zhu; Jiankai Liang; Yaqian Tan; Liwu Fu; Fang Wang; Wei Yin; Bingzheng Lu; Pengxin Qiu; Xingwen Su; Shoufang Gong; Xuetao Bai; Jun Hu; Guangmei Yan

doi:10.1126/scitranslmed.aam7996

Research ArticleCancer

Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma

View ORCID ProfileHaipeng Zhang¹,²,*,
Kai Li¹,³,*,
View ORCID ProfileYuan Lin¹,⁴,*,
Fan Xing¹,
Xiao Xiao¹,⁵,
Jing Cai¹,
Wenbo Zhu¹,
Jiankai Liang¹,⁶,
Yaqian Tan¹,
Liwu Fu⁷,
Fang Wang⁷,
Wei Yin⁸,
Bingzheng Lu¹,
Pengxin Qiu¹,
Xingwen Su¹,
Shoufang Gong⁶,
Xuetao Bai⁶,
Jun Hu⁹,† and
View ORCID ProfileGuangmei Yan¹,†

¹Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
²Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
³Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
⁴Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
⁵Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
⁶Guangzhou Virotech Pharmaceutical Co. Ltd., Guangzhou 510663, China.
⁷State Key Laboratory for Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.
⁸Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
⁹Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

↵†Corresponding author. Email: hujun{at}mail.sysu.edu.cn (J.H.); ygm{at}mail.sysu.edu.cn (G.Y.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 23 Aug 2017:
Vol. 9, Issue 404, eaam7996
DOI: 10.1126/scitranslmed.aam7996

Haipeng Zhang

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

2Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

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ORCID record for Haipeng Zhang

Kai Li

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

3Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.

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Yuan Lin

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

4Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

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Fan Xing

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Xiao Xiao

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

5Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.

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Jing Cai

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Wenbo Zhu

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Jiankai Liang

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

6Guangzhou Virotech Pharmaceutical Co. Ltd., Guangzhou 510663, China.

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Yaqian Tan

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Liwu Fu

7State Key Laboratory for Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

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Fang Wang

7State Key Laboratory for Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

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Wei Yin

8Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Bingzheng Lu

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Pengxin Qiu

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Xingwen Su

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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Shoufang Gong

6Guangzhou Virotech Pharmaceutical Co. Ltd., Guangzhou 510663, China.

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Xuetao Bai

6Guangzhou Virotech Pharmaceutical Co. Ltd., Guangzhou 510663, China.

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Jun Hu

9Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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For correspondence: hujun@mail.sysu.edu.cn ygm@mail.sysu.edu.cn

Guangmei Yan

1Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.

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ORCID record for Guangmei Yan
For correspondence: hujun@mail.sysu.edu.cn ygm@mail.sysu.edu.cn

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Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma

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