Contents
23 August 2017
Vol 9, Issue 404
Vol 9, Issue 404
Research Articles
- A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus
GLP-1R agonists show promise as a therapeutic agent to lower intracranial pressure in rodents.
- Targeting VCP enhances anticancer activity of oncolytic virus M1 in hepatocellular carcinoma
Inhibition of VCP sensitizes hepatocellular carcinoma cells to oncolytic virus M1–induced apoptosis.
- A lower-extremity exoskeleton improves knee extension in children with crouch gait from cerebral palsy
A powered exoskeleton alleviates knee extension deficiency while preserving volitional muscle activity during overground walking in children with cerebral palsy.
Report
- An RNA interference screen identifies druggable regulators of MeCP2 stability
Inhibition of proteins that stabilize MeCP2 is a potential strategy to treat MECP2 duplication syndrome.
Editors' Choice
- A bigger and better picture of clinical samples
An open-top light-sheet microscope enables rapid high-resolution panoramic imaging of intact clinical samples to increase the accuracy and reproducibility of clinical histology.
- Evading sepsis with exercise
Aged mice preconditioned with a running routine were resistant to acute systemic sepsis compared with non-runner.
- “CHIP”s are bad for patients with solid tumors
In patients with nonhematologic cancers, clonal hematopoiesis is prevalent and associated with poor prognoses.
- Cellular eyelashes help striatal neurons hook up
Primary cilia-based signaling provides critical infrastructure for formation of striatal neuronal networks.
About The Cover
ONLINE COVER A FLEX-ible Drug for Hydrocephalus. Hydrocephalus, a disease of newborns in which cerebrospinal fluid accumulates in the brain, can be treated surgically, but this procedure carries risks. Botfield et al. now report that activating the glucagon-like peptide 1 receptor (GLP-1R) in the brain's choroid plexus with FLEX, an analog of a drug currently used to treat diabetes, reduced intracranial pressure in a rat model of hydrocephalus. This cover image depicts fluorescently labeled FLEX (green) bound to neurons (blue) in a slice of rat choroid plexus. The authors used in vitro and in vivo approaches to show that GLP-1R is expressed abundantly in the mammalian choroid plexus and might be a useful therapeutic target for treating hydrocephalus. [CREDIT: BOTFIELD ET AL./SCIENCE TRANSLATIONAL MEDICINE]
