23 August 2017
Vol 9, Issue 404

About The Cover

Cover image expansion

ONLINE COVER A FLEX-ible Drug for Hydrocephalus. Hydrocephalus, a disease of newborns in which cerebrospinal fluid accumulates in the brain, can be treated surgically, but this procedure carries risks. Botfield et al. now report that activating the glucagon-like peptide 1 receptor (GLP-1R) in the brain's choroid plexus with FLEX, an analog of a drug currently used to treat diabetes, reduced intracranial pressure in a rat model of hydrocephalus. This cover image depicts fluorescently labeled FLEX (green) bound to neurons (blue) in a slice of rat choroid plexus. The authors used in vitro and in vivo approaches to show that GLP-1R is expressed abundantly in the mammalian choroid plexus and might be a useful therapeutic target for treating hydrocephalus. [CREDIT: BOTFIELD ET AL./SCIENCE TRANSLATIONAL MEDICINE]