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Research ArticleCancer
Direct detection of early-stage cancers using circulating tumor DNA
- View ORCID ProfileJillian Phallen1,
- Mark Sausen2,
- Vilmos Adleff1,
- View ORCID ProfileAlessandro Leal1,
- Carolyn Hruban1,
- James White1,
- View ORCID ProfileValsamo Anagnostou1,
- View ORCID ProfileJacob Fiksel1,
- View ORCID ProfileStephen Cristiano1,
- View ORCID ProfileEniko Papp1,*,
- View ORCID ProfileSavannah Speir1,
- View ORCID ProfileThomas Reinert3,
- Mai-Britt Worm Orntoft3,
- View ORCID ProfileBrian D. Woodward4,
- View ORCID ProfileDerek Murphy2,
- Sonya Parpart-Li2,
- David Riley2,
- Monica Nesselbush2,
- Naomi Sengamalay2,
- Andrew Georgiadis2,
- Qing Kay Li1,
- Mogens Rørbæk Madsen5,
- Frank Viborg Mortensen6,
- View ORCID ProfileJoost Huiskens7,8,
- View ORCID ProfileCornelis Punt8,
- View ORCID ProfileNicole van Grieken9,
- View ORCID ProfileRemond Fijneman10,
- Gerrit Meijer10,
- Hatim Husain4,
- View ORCID ProfileRobert B. Scharpf1,
- Luis A. Diaz Jr1,†,
- Siân Jones2,
- View ORCID ProfileSam Angiuoli2,
- View ORCID ProfileTorben Ørntoft3,
- View ORCID ProfileHans Jørgen Nielsen11,
- View ORCID ProfileClaus Lindbjerg Andersen3 and
- View ORCID ProfileVictor E. Velculescu1,‡
- 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
- 2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
- 3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
- 4Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
- 5Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.
- 6Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
- 7Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
- 8Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
- 9Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.
- 10Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
- 11Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.
- ↵‡Corresponding author. Email: velculescu{at}jhmi.edu
See allHide authors and affiliations
Science Translational Medicine 16 Aug 2017:
Vol. 9, Issue 403, eaan2415
DOI: 10.1126/scitranslmed.aan2415
Vol. 9, Issue 403, eaan2415
DOI: 10.1126/scitranslmed.aan2415
Jillian Phallen
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mark Sausen
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Vilmos Adleff
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Alessandro Leal
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Carolyn Hruban
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
James White
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Valsamo Anagnostou
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jacob Fiksel
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Stephen Cristiano
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Eniko Papp
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Savannah Speir
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Thomas Reinert
3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Mai-Britt Worm Orntoft
3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Brian D. Woodward
4Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Derek Murphy
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Sonya Parpart-Li
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
David Riley
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Monica Nesselbush
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Naomi Sengamalay
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Andrew Georgiadis
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Qing Kay Li
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mogens Rørbæk Madsen
5Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.
Frank Viborg Mortensen
6Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
Joost Huiskens
7Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
8Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Cornelis Punt
8Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Nicole van Grieken
9Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.
Remond Fijneman
10Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
Gerrit Meijer
10Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
Hatim Husain
4Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Robert B. Scharpf
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Luis A. Diaz Jr
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Siân Jones
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Sam Angiuoli
2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Torben Ørntoft
3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Hans Jørgen Nielsen
11Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.
Claus Lindbjerg Andersen
3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Victor E. Velculescu
1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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