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Research ArticleCancer
Direct detection of early-stage cancers using circulating tumor DNA
- Jillian Phallen1,
- Mark Sausen2,
- Vilmos Adleff1,
- Alessandro Leal1,
- Carolyn Hruban1,
- James White1,
- Valsamo Anagnostou1,
- Jacob Fiksel1,
- Stephen Cristiano1,
- Eniko Papp1,*,
- Savannah Speir1,
- Thomas Reinert3,
- Mai-Britt Worm Orntoft3,
- Brian D. Woodward4,
- Derek Murphy2,
- Sonya Parpart-Li2,
- David Riley2,
- Monica Nesselbush2,
- Naomi Sengamalay2,
- Andrew Georgiadis2,
- Qing Kay Li1,
- Mogens Rørbæk Madsen5,
- Frank Viborg Mortensen6,
- Joost Huiskens7,8,
- Cornelis Punt8,
- Nicole van Grieken9,
- Remond Fijneman10,
- Gerrit Meijer10,
- Hatim Husain4,
- Robert B. Scharpf1,
- Luis A. Diaz Jr1,†,
- Siân Jones2,
- Sam Angiuoli2,
- Torben Ørntoft3,
- Hans Jørgen Nielsen11,
- Claus Lindbjerg Andersen3 and
- Victor E. Velculescu1,‡
- 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
- 2Personal Genome Diagnostics, Baltimore, MD 21224, USA.
- 3Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
- 4Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
- 5Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.
- 6Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
- 7Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
- 8Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
- 9Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.
- 10Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
- 11Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.
- ↵‡Corresponding author. Email: velculescu{at}jhmi.edu
See allHide authors and affiliations
Science Translational Medicine 16 Aug 2017:
Vol. 9, Issue 403, eaan2415
DOI: 10.1126/scitranslmed.aan2415
Vol. 9, Issue 403, eaan2415
DOI: 10.1126/scitranslmed.aan2415
Jillian Phallen
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mark Sausen
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Vilmos Adleff
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Alessandro Leal
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Carolyn Hruban
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
James White
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Valsamo Anagnostou
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jacob Fiksel
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Stephen Cristiano
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Eniko Papp
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Savannah Speir
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Thomas Reinert
Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Mai-Britt Worm Orntoft
Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Brian D. Woodward
Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Derek Murphy
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Sonya Parpart-Li
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
David Riley
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Monica Nesselbush
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Naomi Sengamalay
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Andrew Georgiadis
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Qing Kay Li
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mogens Rørbæk Madsen
Department of Surgery, Herning Regional Hospital, DK-7400 Herning, Denmark.
Frank Viborg Mortensen
Department of Surgical Gastroenterology, Aarhus University Hospital, DK-8000 Aarhus, Denmark.
Joost Huiskens
Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Cornelis Punt
Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Nicole van Grieken
Department of Pathology, VU University Medical Center, Amsterdam 1081 HV, Netherlands.
Remond Fijneman
Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
Gerrit Meijer
Department of Pathology, Netherlands Cancer Institute, Amsterdam 1066 CX, Netherlands.
Hatim Husain
Division of Hematology and Oncology, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Robert B. Scharpf
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Luis A. Diaz
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Siân Jones
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Sam Angiuoli
Personal Genome Diagnostics, Baltimore, MD 21224, USA.
Torben Ørntoft
Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Hans Jørgen Nielsen
Department of Surgical Gastroenterology 360, Hvidovre Hospital, Hvidovre, Denmark.
Claus Lindbjerg Andersen
Department of Molecular Medicine, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Victor E. Velculescu
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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