Research ArticleNeurodegenerative Disease
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
- View ORCID ProfileClaire E. Le Pichon1,*,†,
- View ORCID ProfileWilliam J. Meilandt1,*,‡,
- Sara Dominguez1,
- Hilda Solanoy1,§,
- View ORCID ProfileHan Lin1,
- Hai Ngu2,
- View ORCID ProfileAlvin Gogineni3,
- Arundhati Sengupta Ghosh1,
- Zhiyu Jiang1,
- View ORCID ProfileSeung-Hye Lee1,
- View ORCID ProfileJanice Maloney1,
- View ORCID ProfileVineela D. Gandham3,
- View ORCID ProfileChristine D. Pozniak1,
- Bei Wang1,||,
- View ORCID ProfileSebum Lee4,
- View ORCID ProfileMichael Siu5,
- View ORCID ProfileSnahel Patel5,
- Zora Modrusan6,
- Xingrong Liu7,
- York Rudhard8,
- View ORCID ProfileMiriam Baca2,
- View ORCID ProfileAmy Gustafson9,
- View ORCID ProfileJosh Kaminker10,
- View ORCID ProfileRichard A. D. Carano3,
- View ORCID ProfileEric J. Huang4,11,
- Oded Foreman2,
- Robby Weimer3,
- Kimberly Scearce-Levie1,§ and
- View ORCID ProfileJoseph W. Lewcock1,‡,§
- 1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 2Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 4Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
- 5Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 6Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 7Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 8In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.
- 9Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 10Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 11Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
- ↵‡Corresponding author. Email: lewcock{at}dnli.com (J.W.L.); meilandt.william{at}gene.com (W.J.M.)
↵* These authors contributed equally to this work.
↵† Present address: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
↵§ Present address: Denali Therapeutics, 151 Oyster Point Boulevard, South San Francisco, CA 94080, USA.
↵|| Present address: Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, 435 Weill Hall, Ithaca, NY 14853, USA.
See allHide authors and affiliations
Science Translational Medicine 16 Aug 2017:
Vol. 9, Issue 403, eaag0394
DOI: 10.1126/scitranslmed.aag0394
Vol. 9, Issue 403, eaag0394
DOI: 10.1126/scitranslmed.aag0394
Claire E. Le Pichon
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
William J. Meilandt
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sara Dominguez
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hilda Solanoy
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Han Lin
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hai Ngu
2Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Alvin Gogineni
3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Arundhati Sengupta Ghosh
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Zhiyu Jiang
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Seung-Hye Lee
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Janice Maloney
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Vineela D. Gandham
3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Christine D. Pozniak
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bei Wang
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sebum Lee
4Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael Siu
5Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Snahel Patel
5Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Zora Modrusan
6Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Xingrong Liu
7Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
York Rudhard
8In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.
Miriam Baca
2Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Amy Gustafson
9Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Josh Kaminker
10Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Richard A. D. Carano
3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Eric J. Huang
4Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
11Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
Oded Foreman
2Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Robby Weimer
3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Kimberly Scearce-Levie
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Joseph W. Lewcock
1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
