Research ArticleNeurodegenerative Disease
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
- Claire E. Le Pichon1,*,†,
- William J. Meilandt1,*,‡,
- Sara Dominguez1,
- Hilda Solanoy1,§,
- Han Lin1,
- Hai Ngu2,
- Alvin Gogineni3,
- Arundhati Sengupta Ghosh1,
- Zhiyu Jiang1,
- Seung-Hye Lee1,
- Janice Maloney1,
- Vineela D. Gandham3,
- Christine D. Pozniak1,
- Bei Wang1,||,
- Sebum Lee4,
- Michael Siu5,
- Snahel Patel5,
- Zora Modrusan6,
- Xingrong Liu7,
- York Rudhard8,
- Miriam Baca2,
- Amy Gustafson9,
- Josh Kaminker10,
- Richard A. D. Carano3,
- Eric J. Huang4,11,
- Oded Foreman2,
- Robby Weimer3,
- Kimberly Scearce-Levie1,§ and
- Joseph W. Lewcock1,‡,§
- 1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 2Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 4Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
- 5Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 6Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 7Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 8In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.
- 9Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 10Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
- 11Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
- ↵‡Corresponding author. Email: lewcock{at}dnli.com (J.W.L.); meilandt.william{at}gene.com (W.J.M.)
↵* These authors contributed equally to this work.
↵† Present address: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
↵§ Present address: Denali Therapeutics, 151 Oyster Point Boulevard, South San Francisco, CA 94080, USA.
↵|| Present address: Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, 435 Weill Hall, Ithaca, NY 14853, USA.
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Science Translational Medicine 16 Aug 2017:
Vol. 9, Issue 403, eaag0394
DOI: 10.1126/scitranslmed.aag0394
Vol. 9, Issue 403, eaag0394
DOI: 10.1126/scitranslmed.aag0394
Claire E. Le Pichon
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
William J. Meilandt
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sara Dominguez
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hilda Solanoy
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Han Lin
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Hai Ngu
Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Alvin Gogineni
Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Arundhati Sengupta Ghosh
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Zhiyu Jiang
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Seung-Hye Lee
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Janice Maloney
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Vineela D. Gandham
Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Christine D. Pozniak
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Bei Wang
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sebum Lee
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael Siu
Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Snahel Patel
Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Zora Modrusan
Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Xingrong Liu
Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
York Rudhard
In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.
Miriam Baca
Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Amy Gustafson
Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Josh Kaminker
Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Richard A. D. Carano
Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Eric J. Huang
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
Oded Foreman
Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Robby Weimer
Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Kimberly Scearce-Levie
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Joseph W. Lewcock
Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
