Research ArticleNeurodegenerative Disease

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

See allHide authors and affiliations

Science Translational Medicine  16 Aug 2017:
Vol. 9, Issue 403, eaag0394
DOI: 10.1126/scitranslmed.aag0394

Article Information

vol. 9 no. 403

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication May 4, 2016
  • Resubmitted November 23, 2016
  • Accepted for publication March 27, 2017
  • .

Author Information

  1. Claire E. Le Pichon1,*,,
  2. William J. Meilandt1,*,,
  3. Sara Dominguez1,
  4. Hilda Solanoy1,§,
  5. Han Lin1,
  6. Hai Ngu2,
  7. Alvin Gogineni3,
  8. Arundhati Sengupta Ghosh1,
  9. Zhiyu Jiang1,
  10. Seung-Hye Lee1,
  11. Janice Maloney1,
  12. Vineela D. Gandham3,
  13. Christine D. Pozniak1,
  14. Bei Wang1,||,
  15. Sebum Lee4,
  16. Michael Siu5,
  17. Snahel Patel5,
  18. Zora Modrusan6,
  19. Xingrong Liu7,
  20. York Rudhard8,
  21. Miriam Baca2,
  22. Amy Gustafson9,
  23. Josh Kaminker10,
  24. Richard A. D. Carano3,
  25. Eric J. Huang4,11,
  26. Oded Foreman2,
  27. Robby Weimer3,
  28. Kimberly Scearce-Levie1,§ and
  29. Joseph W. Lewcock1,,§
  1. 1Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  2. 2Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  3. 3Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  4. 4Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  5. 5Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  6. 6Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  7. 7Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  8. 8In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.
  9. 9Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  10. 10Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  11. 11Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
  1. Corresponding author. Email: lewcock{at}dnli.com (J.W.L.); meilandt.william{at}gene.com (W.J.M.)
    • * These authors contributed equally to this work.

    • Present address: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

    • § Present address: Denali Therapeutics, 151 Oyster Point Boulevard, South San Francisco, CA 94080, USA.

    • || Present address: Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, 435 Weill Hall, Ithaca, NY 14853, USA.

    Altmetric

    Article usage

    Article usage: August 2017 to October 2019

    AbstractFullPdf
    Aug 201793455401299
    Sep 20171016169341
    Oct 2017756102248
    Nov 201744332104
    Dec 20173344985
    Jan 20182643665
    Feb 20182143858
    Mar 20182403152
    Apr 20183292553
    May 20183172758
    Jun 20182694055
    Jul 20181723555
    Aug 20186015461
    Sep 20180515123
    Oct 201801088104
    Nov 2018047996
    Dec 20180384107
    Jan 201921344158
    Feb 201940293130
    Mar 201939235188
    Apr 201926140116
    May 20191110275
    Jun 2019165657
    Jul 20193010563
    Aug 2019149367
    Sep 20196101108
    Oct 201943933

    Navigate This Article