16 August 2017
Vol 9, Issue 403

About The Cover

Cover image expansion

ONLINE COVER Turning Back the Clock to Detect Cancer. Tumors shed DNA into patients' blood, where it can be detected, but the amount of DNA is very small early in the course of disease and only increases as the tumor grows. As a result, early tumors that are easier to treat can be difficult or impossible to detect by analyzing circulating tumor DNA. As illustrated in this image, Phallen et al. have developed a method that allows more sensitive detection of smaller amounts of circulating tumor DNA, thereby "turning back the clock" and potentially permitting earlier detection of developing tumors. [CREDIT: CAROLYN HRUBAN, JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE]