Research ArticleCancer

Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance

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Science Translational Medicine  09 Aug 2017:
Vol. 9, Issue 402, eaai7993
DOI: 10.1126/scitranslmed.aai7993

Article Information

vol. 9 no. 402

PubMed: 
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History: 
  • Received for publication August 14, 2016
  • Resubmitted March 30, 2017
  • Accepted for publication June 29, 2017
  • .

Author Information

  1. Jennifer M. Giltnane1,2,*,
  2. Katherine E. Hutchinson3,*,
  3. Thomas P. Stricker1,2,*,
  4. Luigi Formisano3,
  5. Christian D. Young3,
  6. Monica V. Estrada2,
  7. Mellissa J. Nixon4,
  8. Liping Du5,
  9. Violeta Sanchez2,
  10. Paula Gonzalez Ericsson2,
  11. Maria G. Kuba1,
  12. Melinda E. Sanders1,2,
  13. Xinmeng J. Mu6,
  14. Eliezer M. Van Allen6,7,
  15. Nikhil Wagle6,7,
  16. Ingrid A. Mayer2,3,
  17. Vandana Abramson2,3,
  18. Henry Gόmez8,
  19. Monica Rizzo9,
  20. Weiyi Toy10,
  21. Sarat Chandarlapaty10,
  22. Erica L. Mayer7,
  23. Jason Christiansen11,
  24. Danielle Murphy11,
  25. Kerry Fitzgerald11,
  26. Kai Wang12,
  27. Jeffrey S. Ross12,13,
  28. Vincent A. Miller12,
  29. Phillip J. Stephens12,
  30. Roman Yelensky12,
  31. Levi Garraway6,7,14,
  32. Yu Shyr5,
  33. Ingrid Meszoely2,15,
  34. Justin M. Balko2,3,4 and
  35. Carlos L. Arteaga2,3,4,
  1. 1Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  2. 2Breast Cancer Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  3. 3Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  4. 4Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  5. 5Vanderbilt Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  6. 6Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  7. 7Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  8. 8Instituto Nacional de Enfermedades Neoplásicas, Surquillo 15038, Peru.
  9. 9Department of Surgery, Emory University, Atlanta, GA 30322, USA.
  10. 10Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10022, USA.
  11. 11Genoptix Medical Laboratories, Carlsbad, CA 92008, USA.
  12. 12Foundation Medicine Inc., Cambridge, MA 02141, USA.
  13. 13Department of Pathology, Albany Medical College, Albany, NY 12208, USA.
  14. 14Joint Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
  15. 15Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  1. Corresponding author. Email: carlos.arteaga{at}vanderbilt.edu
  • * These authors contributed equally to this work.

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