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Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer

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Science Translational Medicine  02 Aug 2017:
Vol. 9, Issue 401, eaam7049
DOI: 10.1126/scitranslmed.aam7049

Article Information

vol. 9 no. 401

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 6, 2017
  • Resubmitted April 13, 2017
  • Accepted for publication June 29, 2017
  • .

Author Information

  1. Delphine Merino1,2,*,
  2. James R. Whittle1,2,3,*,
  3. François Vaillant1,2,*,
  4. Antonin Serrano1,2,
  5. Jia-Nan Gong2,4,
  6. Goknur Giner2,5,
  7. Ana Leticia Maragno6,
  8. Maïa Chanrion6,
  9. Emilie Schneider6,
  10. Bhupinder Pal1,2,
  11. Xiang Li2,7,
  12. Grant Dewson2,7,
  13. Julius Gräsel1,2,
  14. Kevin Liu1,2,
  15. Najoua Lalaoui2,7,
  16. David Segal2,4,
  17. Marco J. Herold2,8,
  18. David C. S. Huang2,4,
  19. Gordon K. Smyth5,9,
  20. Olivier Geneste6,
  21. Guillaume Lessene2,10,11,
  22. Jane E. Visvader1,2, and
  23. Geoffrey J. Lindeman1,3,12,13,
  1. 1ACRF Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  2. 2Department of Medical Biology, University of Melbourne, Parkville, Victoria 3010, Australia.
  3. 3Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
  4. 4Cancer and Haematology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  5. 5Bioinformatics Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  6. 6Institut de Recherches Servier Oncology R&D Unit, Croissy Sur Seine 78290, France.
  7. 7Cell Signalling and Cell Death Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  8. 8Molecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  9. 9School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria 3010, Australia.
  10. 10Chemical Biology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia.
  11. 11Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia.
  12. 12Department of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia.
  13. 13Parkville Familial Cancer Centre, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Victoria 3050, Australia.
  1. Corresponding author. Email: visvader{at}wehi.edu.au (J.E.V.); lindeman{at}wehi.edu.au (G.J.L.)
    • * These authors contributed equally to this work.

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