Contents
02 August 2017
Vol 9, Issue 401
Vol 9, Issue 401
Focus
- Pinning allergies on pathogenic TH2 cells
A new subtype of TH2 cell emerges as the pathogenic cell type in allergic disease and is deleted during allergen-specific immunotherapy (Wambre et al., this issue).
Research Articles
- A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
A unique T helper cell signature in allergic patients isolates the pathogenic cells and provides a target for disease intervention.
- Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
The MCL-1 inhibitor S63845 is effective in combination with conventional therapy for targeting triple-negative and HER2-amplified breast cancer.
- FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer
Folate-conjugated microRNAs are specifically taken up by tumor cells and inhibit tumor progression in mice.
Report
- Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice
Using optogenetics to modulate the excitation/inhibition balance in the prefrontal cortex of an autism-like mouse model rescued social behavior deficits.
Letters
- Comment on “Using geospatial mapping to design HIV elimination strategies for sub-Saharan Africa”
A recent study showed how geospatial mapping can be used to improve Lesotho’s HIV treatment program to achieve the 90-90-90 targets set by the United Nations but incorrectly describes “treatment as prevention” as the UN’s strategy for a successful national AIDS response.
- Response to comment on “Using geospatial mapping to design HIV elimination strategies for sub-Saharan Africa”
Detailed geospatial mapping of a generalized HIV epidemic in sub-Saharan Africa shows that implementing the UNAIDS 90-90-90 strategy could potentially exacerbate urban-rural health care disparities.
Editors' Choice
- Let’s start from the very beginning
Methicillin-resistant Staphylococcus aureus likely evolved before the introduction of methicillin into clinical use.
- A brilliant approach to study the basis of intelligence?
A new approach may help to explore the genetic levers that control intelligence.
- Burn injuries cast their nets in blood vessels
Neutrophil extraceullar traps (NETs) cause secondary expansion of tissue necrosis in local and remote tissues due to microvascular hypercoagulation.
- Why the sequel is always worse than the original
Severe pneumonia predisposes to recurrent infection by functionally impairing antigen presenting cells.
About The Cover
ONLINE COVER Taming of the TH2. Although scientists have known for a long time that helper T type 2 (TH2) cells are implicated in allergic responses, it is difficult to distinguish harmful TH2 cells from those that fight pathogens. Wambre et al. detected a subset of TH2 cells only in allergic individuals, like the girl pictured here, and saw this subset decrease in patients responding to immunotherapy. As Cousins discusses in the accompanying Focus article, these findings not only pave the way for more accurate studies of allergy pathogenesis, but also suggest that this subset could be specifically targeted for therapy. [CREDIT: SKYNESHER/ISTOCKPHOTO]