Contents
26 July 2017
Vol 9, Issue 400
Vol 9, Issue 400
Focus
- Charting the “unknown unknowns” of cancer progression
Integrated computational and experimental strategies reveal previously unknown regulatory programs underlying metastatic disease.
Research Articles
- A soft robotic exosuit improves walking in patients after stroke
Soft exosuits facilitate more normal walking after stroke.
- Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure
Multiple redundant and diverse intranodal pacemakers and conduction pathways allow the human sinoatrial node to robustly maintain cardiac rhythm.
- Mechanoresponsive stem cells to target cancer metastases through biophysical cues
Targeting the mechano-niche of the tumor microenvironment is a strategy to interrogate, detect, and treat cancer.
- Repression of BET activity sensitizes homologous recombination–proficient cancers to PARP inhibition
PARP inhibitors can be combined with BET inhibitors to treat cancers with de novo or acquired resistance to PARP inhibition.
Editors' Choice
- Inflamm-vestigating inflamm-aging
Monocytes from elderly people respond differently to pattern recognition receptor engagement than monocytes from younger adults.
- Hold your nose to get lean
Decreased olfactory function is associated with lean phenotype, improved peripheral metabolism, and increased energy expenditure during a high-fat diet.
- Comfy wirewear
Nanomesh fabrication creates breathable, stretchable, comfortable, inflammation-free, on-skin conductors without residual polymeric support for wearable biosensors.
- Interferon with antitumor immunity
IFN-γ directs homeostatic differentiation of tissue APCs but may subvert aspects of tumor immune surveillance.
Erratum
About The Cover
ONLINE COVER Computing the Secrets of Metastasis. This image depicts a transfer RNA on a computer screen, illustrating the work of Hani Goodarzi, the winner of this year's AAAS Martin and Rose Wachtel Cancer Research Award, who applies computational strategies to the study of transfer RNA and other aspects of intracellular regulation that affect cancer cells' ability to metastasize. The winner discusses his work in a Focus article and will also present a lecture based on his research on Friday, 28 July 2017, at the National Institutes of Health. [CREDIT: PESHKOV/ISTOCKPHOTO; MOLEKUUL/SCIENCE SOURCE]