Research ArticleCancer
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
- View ORCID ProfileDonald M. O’Rourke1,
- View ORCID ProfileMacLean P. Nasrallah2,*,
- View ORCID ProfileArati Desai3,*,
- View ORCID ProfileJan J. Melenhorst4,*,
- View ORCID ProfileKeith Mansfield5,*,
- View ORCID ProfileJennifer J. D. Morrissette6,
- View ORCID ProfileMaria Martinez-Lage2,†,
- View ORCID ProfileSteven Brem1,
- Eileen Maloney1,
- View ORCID ProfileAngela Shen7,
- View ORCID ProfileRandi Isaacs5,
- Suyash Mohan8,
- View ORCID ProfileGabriela Plesa4,
- View ORCID ProfileSimon F. Lacey4,
- View ORCID ProfileJean-Marc Navenot4,
- View ORCID ProfileZhaohui Zheng4,
- View ORCID ProfileBruce L. Levine4,
- Hideho Okada9,
- View ORCID ProfileCarl H. June4,
- Jennifer L. Brogdon5 and
- View ORCID ProfileMarcela V. Maus10,‡
- 1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
- 6Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 7Novartis Oncology, East Hanover, NJ 07936, USA.
- 8Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 9Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
- 10Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.
- ↵‡Corresponding author. Email: mvmaus{at}mgh.harvard.edu
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Science Translational Medicine 19 Jul 2017:
Vol. 9, Issue 399, eaaa0984
DOI: 10.1126/scitranslmed.aaa0984
Vol. 9, Issue 399, eaaa0984
DOI: 10.1126/scitranslmed.aaa0984
Donald M. O’Rourke
1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
MacLean P. Nasrallah
2Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Arati Desai
3Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Jan J. Melenhorst
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Keith Mansfield
5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Jennifer J. D. Morrissette
6Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Maria Martinez-Lage
2Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Steven Brem
1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Eileen Maloney
1Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Angela Shen
7Novartis Oncology, East Hanover, NJ 07936, USA.
Randi Isaacs
5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Suyash Mohan
8Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Gabriela Plesa
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Simon F. Lacey
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jean-Marc Navenot
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Zhaohui Zheng
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Bruce L. Levine
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hideho Okada
9Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Carl H. June
4Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jennifer L. Brogdon
5Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.
Marcela V. Maus
10Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.
