12 July 2017
Vol 9, Issue 398

About The Cover

Cover image expansion

ONLINE COVER I Spy Inflammation. This image shows a color map depicting fat tissue adjacent to a human coronary artery (light gray). Using computerized tomography imaging, Antonopoulos et al. developed a metric called the perivascular fat attenuation index (FAI), which quantifies changes in fat cell size correlated with inflammation in the underlying artery. The perivascular FAI was increased around ruptured atherosclerotic plaques in patients who had recently experienced heart attacks. With further clinical validation, this noninvasive imaging method could help clinicians monitor inflammation in the coronary arteries, enabling earlier intervention for heart disease. [CREDIT: ANTONOPOULOS ET AL./SCIENCE TRANSLATIONAL MEDICINE]