Research ArticleCancer
Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism
- View ORCID ProfileGeorge S. Karagiannis1,2,*,
- View ORCID ProfileJessica M. Pastoriza1,3,
- Yarong Wang1,2,4,
- Allison S. Harney1,2,4,5,
- View ORCID ProfileDavid Entenberg1,2,4,
- Jeanine Pignatelli1,
- View ORCID ProfileVed P. Sharma1,4,
- Emily A. Xue1,
- Esther Cheng6,
- Timothy M. D’Alfonso6,
- Joan G. Jones1,2,7,8,
- View ORCID ProfileJesus Anampa9,
- Thomas E. Rohan8,
- View ORCID ProfileJoseph A. Sparano9,
- View ORCID ProfileJohn S. Condeelis1,2,4,* and
- View ORCID ProfileMaja H. Oktay1,4,7,*
- 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 3Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
- 4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 5Department of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 6Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
- 7Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA.
- 8Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 9Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
- ↵*Corresponding author. Email: georgios.karagiannis{at}einstein.yu.edu (G.S.K.); john.condeelis{at}einstein.yu.edu (J.S.C.); maja.oktay{at}einstein.yu.edu (M.H.O.)
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Science Translational Medicine 05 Jul 2017:
Vol. 9, Issue 397, eaan0026
DOI: 10.1126/scitranslmed.aan0026
Vol. 9, Issue 397, eaan0026
DOI: 10.1126/scitranslmed.aan0026
George S. Karagiannis
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jessica M. Pastoriza
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Yarong Wang
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Allison S. Harney
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
5Department of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
David Entenberg
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jeanine Pignatelli
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Ved P. Sharma
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Emily A. Xue
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Esther Cheng
6Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Timothy M. D’Alfonso
6Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Joan G. Jones
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
7Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA.
8Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Jesus Anampa
9Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
Thomas E. Rohan
8Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Joseph A. Sparano
9Department of Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.
John S. Condeelis
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
2Integrated Imaging Program, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Maja H. Oktay
1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
4Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
7Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA.
