Contents
05 July 2017
Vol 9, Issue 397
Vol 9, Issue 397
Perspective
- Marketing of unproven stem cell–based interventions: A call to action
Commercial promotion of unsupported therapeutic uses of stem cells is a global problem that should be addressed by coordinated approaches at the national and international levels.
Research Articles
- Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism
Chemotherapy induces prometastatic changes in breast cancer, reversible by TIE2 or MENA inhibition.
- Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
An autoantibody target on brain microvascular endothelial cells in patients with neuromyelitis optica may be exploited to manipulate blood-brain barrier permeability.
- Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis
Genomic and functional analyses of staphylococcal strain specificity reveal roles for microbes in human atopic dermatitis pathogenesis.
Report
- Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis
Previously parasitized erythrocytes in patients with severe malaria retain the parasite protein HRP2, which can be used to predict hemolysis induced by the drug artesunate.
Editors' Choice
- Eccentric implants stand alone
Controlling antibiotic drug clustering in replacement joint material provides a single-step strategy to clear infection while maintaining the mechanical strength needed for load bearing.
- Defining targets to defeat hidradenitis suppurativa
Immunological data implicates IL-17 pathway in the pathogenesis of hidradenitis suppurativa.
- Enduring scars of cocaine
Long-lasting metabolic changes within the brain upon abstinence from cocaine self-administration may increase risk for relapse.
- Self-tanning cells, the new SPF
A skin-penetrant small molecule activates melanin production to protect cells from cancer-inducing ultraviolet damage.
About The Cover
ONLINE COVER A Dangerous Outburst. This image depicts a tumor in a mouse model of breast cancer that was treated with paclitaxel. The tumor cells are green, macrophages are blue, and blood vessels are indicated in red. After paclitaxel treatment, Karagiannis et al. observed an increased incidence of TMEM structures, which consist of tumor cells, macrophages, and endothelial cells, and which facilitate the entry of tumor cells into the vasculature. An area of contact between red, blue, and green colors near the top of the image depicts one such TMEM structure, where blood vessel integrity is disrupted in a phenomenon called "bursting." [CREDIT: KARAGIANNIS ET AL./SCIENCE TRANSLATIONAL MEDICINE]