05 July 2017
Vol 9, Issue 397

About The Cover

Cover image expansion

ONLINE COVER A Dangerous Outburst. This image depicts a tumor in a mouse model of breast cancer that was treated with paclitaxel. The tumor cells are green, macrophages are blue, and blood vessels are indicated in red. After paclitaxel treatment, Karagiannis et al. observed an increased incidence of TMEM structures, which consist of tumor cells, macrophages, and endothelial cells, and which facilitate the entry of tumor cells into the vasculature. An area of contact between red, blue, and green colors near the top of the image depicts one such TMEM structure, where blood vessel integrity is disrupted in a phenomenon called "bursting." [CREDIT: KARAGIANNIS ET AL./SCIENCE TRANSLATIONAL MEDICINE]