Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Research ArticleEMERGING INFECTIONS

¹Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
²Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
³Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
⁴Gilead Sciences Inc., Foster City, CA 94404, USA.
⁵Division of Infectious Diseases, Department of Pediatrics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

↵†Corresponding author. Email: mark.denison{at}vanderbilt.edu (M.R.D.); rbaric{at}email.unc.edu (R.S.B.)

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Science Translational Medicine 28 Jun 2017:
Vol. 9, Issue 396, eaal3653
DOI: 10.1126/scitranslmed.aal3653

Timothy P. Sheahan

1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Amy C. Sims

1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Rachel L. Graham

1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Vineet D. Menachery

1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Lisa E. Gralinski

1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

James B. Case

2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Sarah R. Leist

1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Krzysztof Pyrc

3Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.

Joy Y. Feng