Research ArticleEMERGING INFECTIONS
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
- View ORCID ProfileTimothy P. Sheahan1,*,
- View ORCID ProfileAmy C. Sims1,*,
- View ORCID ProfileRachel L. Graham1,
- Vineet D. Menachery1,
- View ORCID ProfileLisa E. Gralinski1,
- James B. Case2,
- Sarah R. Leist1,
- View ORCID ProfileKrzysztof Pyrc3,
- View ORCID ProfileJoy Y. Feng4,
- Iva Trantcheva4,
- View ORCID ProfileRoy Bannister4,
- Yeojin Park4,
- View ORCID ProfileDarius Babusis4,
- View ORCID ProfileMichael O. Clarke4,
- View ORCID ProfileRichard L. Mackman4,
- View ORCID ProfileJamie E. Spahn4,
- View ORCID ProfileChristopher A. Palmiotti4,
- Dustin Siegel4,
- View ORCID ProfileAdrian S. Ray4,
- Tomas Cihlar4,
- Robert Jordan4,
- Mark R. Denison5,† and
- View ORCID ProfileRalph S. Baric1,†
- 1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- 2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
- 3Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
- 4Gilead Sciences Inc., Foster City, CA 94404, USA.
- 5Division of Infectious Diseases, Department of Pediatrics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
- ↵†Corresponding author. Email: mark.denison{at}vanderbilt.edu (M.R.D.); rbaric{at}email.unc.edu (R.S.B.)
↵* These authors contributed equally to this work.
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Science Translational Medicine 28 Jun 2017:
Vol. 9, Issue 396, eaal3653
DOI: 10.1126/scitranslmed.aal3653
Vol. 9, Issue 396, eaal3653
DOI: 10.1126/scitranslmed.aal3653
Timothy P. Sheahan
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Amy C. Sims
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Rachel L. Graham
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Vineet D. Menachery
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lisa E. Gralinski
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
James B. Case
2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Sarah R. Leist
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Krzysztof Pyrc
3Department of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Joy Y. Feng
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Iva Trantcheva
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Roy Bannister
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Yeojin Park
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Darius Babusis
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Michael O. Clarke
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Richard L. Mackman
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Jamie E. Spahn
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Christopher A. Palmiotti
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Dustin Siegel
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Adrian S. Ray
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Tomas Cihlar
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Robert Jordan
4Gilead Sciences Inc., Foster City, CA 94404, USA.
Mark R. Denison
5Division of Infectious Diseases, Department of Pediatrics and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ralph S. Baric
1Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.