21 June 2017
Vol 9, Issue 395

About The Cover

Cover image expansion

ONLINE COVER The Secret Life of Fibroblasts. Fibroblasts produce extracellular matrix proteins in response to cardiac injury. Micheletti et al. identified a long noncoding RNA, Wisper, up-regulated in cardiac fibroblasts in mice after myocardial infarction. They determined that Wisper contributes to fibrosis during pathogenic cardiac remodeling by regulating cardiac fibroblast proliferation, survival, and matrix production. Inhibiting Wisper in mice after myocardial infarction reduced cardiac dysfunction and scar size. WISPER is conserved in humans and is increased in heart tissue from patients with aortic stenosis, suggesting that targeting this long noncoding RNA could help treat cardiac fibrosis. [CREDIT: LUNAMARINA/ISTOCKPHOTO]