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Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS

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Science Translational Medicine  14 Jun 2017:
Vol. 9, Issue 394, eaal5253
DOI: 10.1126/scitranslmed.aal5253

Article Information

vol. 9 no. 394

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 7, 2016
  • Accepted for publication April 21, 2017
  • .

Author Information

  1. Sarah J. Ross1,*,
  2. Alexey S. Revenko2,*,
  3. Lyndsey L. Hanson3,
  4. Rebecca Ellston3,
  5. Anna Staniszewska1,
  6. Nicky Whalley1,
  7. Sanjay K. Pandey2,
  8. Mitchell Revill3,
  9. Claire Rooney1,
  10. Linda K. Buckett3,
  11. Stephanie K. Klein1,
  12. Kevin Hudson3,
  13. Brett P. Monia2,
  14. Michael Zinda4,
  15. David C. Blakey3,
  16. Paul D. Lyne4, and
  17. A. Robert Macleod2,
  1. 1AstraZeneca, Cambridge CB2 0AA, UK.
  2. 2Ionis Pharmaceuticals, Carlsbad, CA 92010, USA.
  3. 3AstraZeneca, Macclesfield SK10 4TG, UK.
  4. 4AstraZeneca, Waltham, MA 02451, USA.
  1. Corresponding author. Email: paul.lyne{at}astrazeneca.com (P.D.L.); rmacleod{at}ionisph.com (A.R.M.)
    • * These authors contributed equally to this work.

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