Research ArticleCancer

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors

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Science Translational Medicine  14 Jun 2017:
Vol. 9, Issue 394, eaah6144
DOI: 10.1126/scitranslmed.aah6144

Article Information

vol. 9 no. 394

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History: 
  • Received for publication July 21, 2016
  • Resubmitted February 3, 2017
  • Accepted for publication March 21, 2017
  • .

Author Information

  1. Dennis Plenker1,2,*,
  2. Maximilian Riedel1,2,*,
  3. Johannes Brägelmann1,2,
  4. Marcel A. Dammert1,2,
  5. Rakhee Chauhan3,
  6. Phillip P. Knowles3,
  7. Carina Lorenz1,2,
  8. Marina Keul4,
  9. Mike Bührmann4,
  10. Oliver Pagel5,
  11. Verena Tischler2,
  12. Andreas H. Scheel6,
  13. Daniel Schütte2,
  14. Yanrui Song7,
  15. Justina Stark4,
  16. Florian Mrugalla4,
  17. Yannic Alber4,
  18. André Richters4,
  19. Julian Engel4,
  20. Frauke Leenders8,
  21. Johannes M. Heuckmann8,
  22. Jürgen Wolf9,
  23. Joachim Diebold10,
  24. Georg Pall11,
  25. Martin Peifer2,
  26. Maarten Aerts12,13,
  27. Kris Gevaert12,13,
  28. René P. Zahedi5,
  29. Reinhard Buettner6,
  30. Kevan M. Shokat14,
  31. Neil Q. McDonald3,15,
  32. Stefan M. Kast4,
  33. Oliver Gautschi10,,
  34. Roman K. Thomas2,9,16, and
  35. Martin L. Sos1,2,,
  1. 1Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.
  2. 2Department of Translational Genomics, Center of Integrated Oncology Cologne–Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.
  3. 3Structural Biology Laboratory, Francis Crick Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK.
  4. 4Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany.
  5. 5Leibniz-Institut für Analytische Wissenschaften–ISAS–e.V., Dortmund, Germany.
  6. 6Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.
  7. 7Crown BioScience, Inc., 3375 Scott Blvd, Suite 108, Santa Clara, CA 95054, USA.
  8. 8NEO New Oncology GmbH, 51105 Cologne, Germany.
  9. 9Department of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital Cologne, Cologne, 50931 Cologne, Germany.
  10. 10Cancer Center, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland.
  11. 11Department of Internal Medicine 5, University Hospital Innsbruck, Haematology/Oncology, Anichstraße 35, 6020 Innsbruck, Austria.
  12. 12VIB-UGent Center for Medical Biotechnology, VIB, B-9000 Ghent, Belgium.
  13. 13Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium.
  14. 14Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA.
  15. 15Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, Malet Street, London WC1E 7HX, UK.
  16. 16German Cancer Consortium (DKTK), partner site Heidelberg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  1. Corresponding author. Email: martin.sos{at}uni-koeln.de
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

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