Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Annika S. Axelsson; Emily Tubbs; Brig Mecham; Shaji Chacko; Hannah A. Nenonen; Yunzhao Tang; Jed W. Fahey; Jonathan M. J. Derry; Claes B. Wollheim; Nils Wierup; Morey W. Haymond; Stephen H. Friend; Hindrik Mulder; Anders H. Rosengren

doi:10.1126/scitranslmed.aah4477

Research ArticleDiabetes

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Annika S. Axelsson¹,
Emily Tubbs¹,
Brig Mecham²,
Shaji Chacko³,
Hannah A. Nenonen¹,
Yunzhao Tang¹,
Jed W. Fahey⁴,
Jonathan M. J. Derry⁵,
Claes B. Wollheim¹,⁶,
Nils Wierup¹,
Morey W. Haymond³,
Stephen H. Friend⁵,
Hindrik Mulder¹ and
Anders H. Rosengren¹,⁵,⁷,*

¹Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.
²Trialomics, Seattle, WA 98115, USA.
³U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
⁴Departments of Medicine, Pharmacology and Molecular Sciences, and International Health, and Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.
⁵Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
⁶Department of Cell Physiology and Metabolism, University Medical Center, CH-1211 Geneva, Switzerland.
⁷Institute of Neuroscience and Physiology, University of Gothenburg, SE-40530 Göteborg, Sweden.

↵*Corresponding author. Email: anders.rosengren{at}gu.se

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Science Translational Medicine 14 Jun 2017:
Vol. 9, Issue 394, eaah4477
DOI: 10.1126/scitranslmed.aah4477

Annika S. Axelsson

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

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Emily Tubbs

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

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Brig Mecham

Trialomics, Seattle, WA 98115, USA.

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Shaji Chacko

U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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Hannah A. Nenonen

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

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Yunzhao Tang

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

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Jed W. Fahey

Departments of Medicine, Pharmacology and Molecular Sciences, and International Health, and Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.

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Jonathan M. J. Derry

Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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Claes B. Wollheim

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Department of Cell Physiology and Metabolism, University Medical Center, CH-1211 Geneva, Switzerland.

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Nils Wierup

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

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Morey W. Haymond

U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

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Stephen H. Friend

Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

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Hindrik Mulder

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

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Anders H. Rosengren

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

Institute of Neuroscience and Physiology, University of Gothenburg, SE-40530 Göteborg, Sweden.

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For correspondence: anders.rosengren@gu.se

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RE: Sulforaphane Increases Testosterone which Decreases Type 2 Diabetes
- James Michael Howard, Biologist, independent
(15 June 2017)

I suggest the basis of these findings is increased testosterone.

Low testosterone may be the basis of the symptoms called type 2 diabetes. It is known that sulforaphane increases testosterone. (Testosterone is not mentioned in this article, at least not in the material available at Science Translational Medicine.)

Competing Interests: None declared.

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Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

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