Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Annika S. Axelsson; Emily Tubbs; Brig Mecham; Shaji Chacko; Hannah A. Nenonen; Yunzhao Tang; Jed W. Fahey; Jonathan M. J. Derry; Claes B. Wollheim; Nils Wierup; Morey W. Haymond; Stephen H. Friend; Hindrik Mulder; Anders H. Rosengren

doi:10.1126/scitranslmed.aah4477

Research ArticleDiabetes

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Annika S. Axelsson¹,
Emily Tubbs¹,
Brig Mecham²,
Shaji Chacko³,
Hannah A. Nenonen¹,
Yunzhao Tang¹,
Jed W. Fahey⁴,
Jonathan M. J. Derry⁵,
Claes B. Wollheim¹,⁶,
Nils Wierup¹,
Morey W. Haymond³,
Stephen H. Friend⁵,
Hindrik Mulder¹ and
Anders H. Rosengren¹,⁵,⁷,*

¹Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.
²Trialomics, Seattle, WA 98115, USA.
³U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
⁴Departments of Medicine, Pharmacology and Molecular Sciences, and International Health, and Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.
⁵Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.
⁶Department of Cell Physiology and Metabolism, University Medical Center, CH-1211 Geneva, Switzerland.
⁷Institute of Neuroscience and Physiology, University of Gothenburg, SE-40530 Göteborg, Sweden.

↵*Corresponding author. Email: anders.rosengren{at}gu.se

See allHide authors and affiliations

Science Translational Medicine 14 Jun 2017:
Vol. 9, Issue 394, eaah4477
DOI: 10.1126/scitranslmed.aah4477

Annika S. Axelsson

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Annika S. Axelsson

Emily Tubbs

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Emily Tubbs

Brig Mecham

Trialomics, Seattle, WA 98115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Brig Mecham

Shaji Chacko

U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Shaji Chacko

Hannah A. Nenonen

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hannah A. Nenonen

Yunzhao Tang

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jed W. Fahey

Departments of Medicine, Pharmacology and Molecular Sciences, and International Health, and Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jed W. Fahey

Jonathan M. J. Derry

Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Claes B. Wollheim

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.Department of Cell Physiology and Metabolism, University Medical Center, CH-1211 Geneva, Switzerland.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Claes B. Wollheim

Nils Wierup

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nils Wierup

Morey W. Haymond

U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Morey W. Haymond

Stephen H. Friend

Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Stephen H. Friend

Hindrik Mulder

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anders H. Rosengren

Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.Institute of Neuroscience and Physiology, University of Gothenburg, SE-40530 Göteborg, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Anders H. Rosengren
For correspondence: anders.rosengren@gu.se

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

RE: Sulforaphane Increases Testosterone which Decreases Type 2 Diabetes
- James Michael Howard, Biologist, independent
(15 June 2017)

I suggest the basis of these findings is increased testosterone.

Low testosterone may be the basis of the symptoms called type 2 diabetes. It is known that sulforaphane increases testosterone. (Testosterone is not mentioned in this article, at least not in the material available at Science Translational Medicine.)

Competing Interests: None declared.

View Full Text

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools