Contents
14 June 2017
Vol 9, Issue 394
Vol 9, Issue 394
Research Articles
- Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction
Donor nonclassical monocytes mediate primary lung allograft dysfunction by recruiting neutrophils via MyD88-dependent production of CXCL2.
- Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Sulforaphane, a natural compound identified by drug repurposing, reduces hepatic glucose production and improves glucose control in type 2 diabetes.
- Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors
An examination of the activity profiles of RET inhibitors suggests potential treatment for RET-rearranged cancers.
- Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS
AZD4785 is a therapeutic antisense oligonucleotide targeting KRAS mRNA with promising preclinical antitumor activity and a favorable safety profile.
Editors' Choice
- It’s reticulated: Diabetes, atherosclerosis, and reticulated platelets
New research describes regulatory pathways for reticulated thrombocytosis in a mouse model of diabetes.
- Immunity at the forefront of the brain: A new genetic model of FTD
Functional characterization of a genetic variant linked to frontotemporal dementia in a murine model reveals deficits in cerebral immune response and metabolism.
- Neutrophils: Double agents for TB
Nitric oxide restricts growth of Mycobacterium tuberculosis by repressing neutrophilic inflammation.
- A vitamin to D-crease sunburn
High doses of oral vitamin D3 attenuate skin inflammation following experimentally induced sun damage.
About The Cover
ONLINE COVER Stowaway Cells Foster Graft Failure. Primary graft dysfunction can result in transplantation failure. Zheng et al. used mouse models of lung transplantation and examined human donor lung tissue to determine if there were cells present in the donor organ that initiated this response. They found that nonclassical monocytes recruited destructive neutrophils, known mediators of primary graft dysfunction. These results suggest that depletion of nonclassical monocytes in donor tissue, like the one pictured here, could improve the rate of organ transplantation success. [CREDIT: ZHENG ET AL./SCIENCE TRANSLATIONAL MEDICINE]
