14 June 2017
Vol 9, Issue 394

About The Cover

Cover image expansion

ONLINE COVER Stowaway Cells Foster Graft Failure. Primary graft dysfunction can result in transplantation failure. Zheng et al. used mouse models of lung transplantation and examined human donor lung tissue to determine if there were cells present in the donor organ that initiated this response. They found that nonclassical monocytes recruited destructive neutrophils, known mediators of primary graft dysfunction. These results suggest that depletion of nonclassical monocytes in donor tissue, like the one pictured here, could improve the rate of organ transplantation success. [CREDIT: ZHENG ET AL./SCIENCE TRANSLATIONAL MEDICINE]