Research ArticleCancer

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

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Science Translational Medicine  07 Jun 2017:
Vol. 9, Issue 393, eaal4922
DOI: 10.1126/scitranslmed.aal4922

Article Information

vol. 9 no. 393

PubMed: 
Print ISSN: 
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History: 
  • Received for publication November 29, 2016
  • Resubmitted March 31, 2017
  • Accepted for publication May 17, 2017

Author Information

  1. Emma Nolan1,2,
  2. Peter Savas3,4,*,
  3. Antonia N. Policheni2,5,*,
  4. Phillip K. Darcy4,6,
  5. François Vaillant1,2,
  6. Christopher P. Mintoff3,
  7. Sathana Dushyanthen3,4,
  8. Mariam Mansour3,4,
  9. Jia-Min B. Pang7,8,
  10. Stephen B. Fox4,7,8,
  11. Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab),
  12. Charles M. Perou9,10,11,
  13. Jane E. Visvader1,2,
  14. Daniel H. D. Gray2,5,,
  15. Sherene Loi3,4,,§ and
  16. Geoffrey J. Lindeman1,12,13,,§
  1. 1Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
  2. 2Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
  3. 3Division of Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  4. 4The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.
  5. 5Molecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
  6. 6Immunotherapy Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  7. 7Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  8. 8Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
  9. 9Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  10. 10Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  11. 11Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  12. 12Parkville Integrated Familial Cancer Centre, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Parkville, Victoria, Australia.
  13. 13Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.
  1. §Corresponding author. Email: sherene.loi{at}petermac.org (S.L.); lindeman{at}wehi.edu.au (G.J.L.)
    • * These authors contributed equally to this work.

    • The full list of consortium members and their affiliations is listed at the end of the acknowledgements.

    • These authors contributed equally to this work.

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