Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

Frank Liang; Gustaf Lindgren; Kerrie J. Sandgren; Elizabeth A. Thompson; Joseph R. Francica; Anja Seubert; Ennio De Gregorio; Susan Barnett; Derek T. O’Hagan; Nancy J. Sullivan; Richard A. Koup; Robert A. Seder; Karin Loré

doi:10.1126/scitranslmed.aal2094

Research ArticleVaccines

Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

View ORCID ProfileFrank Liang¹,²,
View ORCID ProfileGustaf Lindgren¹,²,
Kerrie J. Sandgren¹,*,
Elizabeth A. Thompson¹,²,
Joseph R. Francica³,
View ORCID ProfileAnja Seubert⁴,
Ennio De Gregorio⁴,
Susan Barnett⁵,†,
Derek T. O’Hagan⁵,
Nancy J. Sullivan³,
Richard A. Koup³,
Robert A. Seder³ and
View ORCID ProfileKarin Loré¹,²,‡

¹Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
²Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
³Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁴GSK Vaccines, Siena, Italy.
⁵GSK Vaccines, Rockville, MD 20850, USA.

↵‡Corresponding author. Email: karin.lore{at}ki.se

↵* Present address: Centre for Virus Research, Westmead Institute for Medical Research, Sydney, New South Wales, Australia.
↵† Present address: Bill and Melinda Gates Foundation, Seattle, WA 98109, USA.

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Science Translational Medicine 07 Jun 2017:
Vol. 9, Issue 393, eaal2094
DOI: 10.1126/scitranslmed.aal2094

Frank Liang

1Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

2Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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ORCID record for Frank Liang

Gustaf Lindgren

1Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

2Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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Kerrie J. Sandgren

1Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

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Elizabeth A. Thompson

1Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

2Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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Joseph R. Francica

3Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Anja Seubert

4GSK Vaccines, Siena, Italy.

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Ennio De Gregorio

4GSK Vaccines, Siena, Italy.

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Susan Barnett

5GSK Vaccines, Rockville, MD 20850, USA.

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Derek T. O’Hagan

5GSK Vaccines, Rockville, MD 20850, USA.

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Nancy J. Sullivan

3Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Richard A. Koup

3Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Robert A. Seder

3Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Karin Loré

1Immunology and Allergy Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

2Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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For correspondence: karin.lore@ki.se

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Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake

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