Research ArticleGENETIC DISORDERS

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

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Science Translational Medicine  07 Jun 2017:
Vol. 9, Issue 393, eaal1669
DOI: 10.1126/scitranslmed.aal1669

Article Information

vol. 9 no. 393

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 6, 2016
  • Resubmitted January 10, 2017
  • Accepted for publication April 25, 2017
  • .

Author Information

  1. Shira G. Ziegler1,*,
  2. Carlos R. Ferreira2,
  3. Elena Gallo MacFarlane1,
  4. Ryan C. Riddle3,4,
  5. Ryan E. Tomlinson3,
  6. Emily Y. Chew5,
  7. Ludovic Martin6,
  8. Chen-Ting Ma7,
  9. Eduard Sergienko7,
  10. Anthony B. Pinkerton7,
  11. José Luis Millán7,
  12. William A. Gahl2 and
  13. Harry C. Dietz1,8,*
  1. 1Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  2. 2Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20814, USA.
  3. 3Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  4. 4Baltimore Veterans Administrations Medical Center, Baltimore, MD 21201, USA.
  5. 5National Eye Institute, National Institutes of Health, Bethesda, MD 20814, USA.
  6. 6PXE Reference Center and MitoVasc Institute, Angers University Hospital, Angers, France.
  7. 7Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  8. 8Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  1. *Corresponding author. Email: sgziegler{at}jhmi.edu (S.G.Z.); hdietz{at}jhmi.edu (H.C.D.)

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