Contents
07 June 2017
Vol 9, Issue 393
Vol 9, Issue 393
Research Articles
- Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer
BRCA1-mutated tumors may be particularly vulnerable to dual checkpoint inhibition.
- Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake
Vaccine responses are initiated in vaccine-draining lymph nodes and depend on the efficiency by which adjuvants influence antigen uptake.
- Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase
Ectopic calcification in PXE integrates both local and systemic perturbations of extracellular ATP metabolism and can be attenuated with a TNAP inhibitor.
- The effects of treatment failure generalize across different routes of drug administration
A change in route of drug administration is not sufficient to counter carry-over effects of treatment failure to subsequent treatment attempts.
Report
- Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age
Functional brain imaging of 6-month-old infants with a high familial risk for autism predicts a diagnosis of autism at 24 months of age.
Editors' Choice
- Anti-VEGF AAV2 injections: The fewer the better
A single intravitreal injection of AAV2 provides sustained delivery of anti-VEGF protein for the treatment of neovascular AMD.
- Driver mutations take the wheel in invasive yet nonmalignant disease
Despite their low risk for malignant transformation, infiltrating endometriotic lesions harbor cancer-associated mutations.
- Congenital Zika virus infection: More than just microcephaly
A nonhuman primate model demonstrates efficient vertical transmission of Zika virus.
- Rett syndrome modeling goes simian
Rett syndrome modeling in monkey mirrors the human disorder.
- Modeling human brain development
Human forebrain spheroids enable in vitro observation of region-specific neural migration and circuit formation during brain development.
Retraction
About The Cover
ONLINE COVER Teaming Up Against Breast Cancer. Breast cancer is generally difficult to treat with immunotherapy, even for tumors with high numbers of potentially immunogenic mutations, such as those with mutant BRCA1, a protein involved in DNA repair. Nolan et al. determined that successful immunotherapy against BRCA1-mutated tumors, such as the one shown in the image, requires a combination approach, and demonstrated the effectiveness of combining two immune checkpoint inhibitors and DNA-damaging chemotherapy in this cancer type. [CREDIT: NOLAN ET AL./SCIENCE TRANSLATIONAL MEDICINE; H.M. HALSE]