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A new therapeutic target for myelofibrosis is cause for Gli

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Science Translational Medicine  31 May 2017:
Vol. 9, Issue 392, eaan4297
DOI: 10.1126/scitranslmed.aan4297


Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.

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