Research ArticleCancer

Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers

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Science Translational Medicine  31 May 2017:
Vol. 9, Issue 392, eaal5148
DOI: 10.1126/scitranslmed.aal5148

Article Information

vol. 9 no. 392

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 1, 2016
  • Accepted for publication March 29, 2017
  • .

Author Information

  1. Chaoyang Sun1,2,*,
  2. Yong Fang1,
  3. Jun Yin1,
  4. Jian Chen1,3,
  5. Zhenlin Ju4,
  6. Dong Zhang1,
  7. Xiaohua Chen1,
  8. Christopher P. Vellano1,
  9. Kang Jin Jeong1,
  10. Patrick Kwok-Shing Ng5,
  11. Agda Karina B. Eterovic1,
  12. Neil H. Bhola6,
  13. Yiling Lu1,
  14. Shannon N. Westin7,
  15. Jennifer R. Grandis6,
  16. Shiaw-Yih Lin1,
  17. Kenneth L. Scott8,
  18. Guang Peng9,
  19. Joan Brugge10 and
  20. Gordon B. Mills1
  1. 1Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  2. 2Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  3. 3Department of General Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Province, Hangzhou 310000, China.
  4. 4Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  5. 5Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  6. 6Provost Office, University of California, San Francisco, San Francisco, CA 94158, USA.
  7. 7Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  8. 8Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
  9. 9Department of Clinical Cancer Prevention, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  10. 10Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.
  1. *Corresponding author. Email: csun5{at}mdanderson.org

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