Research ArticlePain

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

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Science Translational Medicine  31 May 2017:
Vol. 9, Issue 392, eaal3447
DOI: 10.1126/scitranslmed.aal3447

Article Information

vol. 9 no. 392

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication November 4, 2016
  • Accepted for publication March 17, 2017
  • .

Author Information

  1. Dane D. Jensen1,2,*,
  2. TinaMarie Lieu1,2,*,
  3. Michelle L. Halls1,*,
  4. Nicholas A. Veldhuis1,2,
  5. Wendy L. Imlach3,
  6. Quynh N. Mai1,2,
  7. Daniel P. Poole1,2,
  8. Tim Quach1,2,
  9. Luigi Aurelio1,2,
  10. Joshua Conner1,2,
  11. Carmen Klein Herenbrink1,2,
  12. Nicholas Barlow1,
  13. Jamie S. Simpson1,
  14. Martin J. Scanlon1,
  15. Bimbil Graham1,
  16. Adam McCluskey4,
  17. Phillip J. Robinson5,
  18. Virginie Escriou6,
  19. Romina Nassini7,
  20. Serena Materazzi7,
  21. Pierangelo Geppetti7,
  22. Gareth A. Hicks8,
  23. Macdonald J. Christie3,
  24. Christopher J. H. Porter1,2,,
  25. Meritxell Canals1,2, and
  26. Nigel W. Bunnett1,2,9,10,
  1. 1Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
  2. 2Australia Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria 3052, Australia.
  3. 3Discipline of Pharmacology, University of Sydney, New South Wales 2006, Australia.
  4. 4School of Environmental and Life Sciences, University of Newcastle, New South Wales 2308, Australia.
  5. 5Children’s Medical Research Institute, University of Sydney, New South Wales 2145, Australia.
  6. 6Unité de Technologies Chimiques et Biologiques pour la Sante, CNRS UMR8258, INSERM U1022, Université Paris Descartes, Chimie ParisTech, 75006 Paris, France.
  7. 7Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, 6-50139 Florence, Italy.
  8. 8Takeda Pharmaceuticals, Boston, MA 02139, USA.
  9. 9Department of Pharmacology and Therapeutics, University of Melbourne, Victoria 3010, Australia.
  10. 10Departments of Surgery and Pharmacology, Columbia University College of Physicians and Surgeons, Columbia University, 21 Audubon Avenue, Room 209, New York City, NY 10032, USA.
  1. Corresponding author. Email: nb2733{at}cumc.columbia.edu (N.W.B.); chris.porter{at}monash.edu (C.J.H.P.); meri.canals{at}monash.edu (M.C.)
    • * These authors contributed equally to this work.

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