Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Qiaoqiao Shi; Saba Chowdhury; Rong Ma; Kevin X. Le; Soyon Hong; Barbara J. Caldarone; Beth Stevens; Cynthia A. Lemere

doi:10.1126/scitranslmed.aaf6295

Research ArticleAlzheimer’s Disease

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

View ORCID ProfileQiaoqiao Shi¹,²,
View ORCID ProfileSaba Chowdhury¹,
View ORCID ProfileRong Ma¹,
View ORCID ProfileKevin X. Le¹,
View ORCID ProfileSoyon Hong²,³,
Barbara J. Caldarone²,⁴,
View ORCID ProfileBeth Stevens²,³ and
View ORCID ProfileCynthia A. Lemere¹,²,*

¹Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.
²Harvard Medical School, Boston, MA 02115, USA.
³Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Center for Life Sciences, 12th Floor, 300 Longwood Avenue, Boston, MA 02115, USA.
⁴Harvard NeuroDiscovery Center NeuroBehavior Laboratory, Department of Neurology, Brigham and Women’s Hospital, Harvard Institute of Medicine, Room 945, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

↵*Corresponding author. Email: clemere{at}bwh.harvard.edu

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Science Translational Medicine 31 May 2017:
Vol. 9, Issue 392, eaaf6295
DOI: 10.1126/scitranslmed.aaf6295

Qiaoqiao Shi

1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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ORCID record for Qiaoqiao Shi

Saba Chowdhury

1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.

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ORCID record for Saba Chowdhury

Rong Ma

1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.

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Kevin X. Le

1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.

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Soyon Hong

2Harvard Medical School, Boston, MA 02115, USA.

3Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Center for Life Sciences, 12th Floor, 300 Longwood Avenue, Boston, MA 02115, USA.

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Barbara J. Caldarone

2Harvard Medical School, Boston, MA 02115, USA.

4Harvard NeuroDiscovery Center NeuroBehavior Laboratory, Department of Neurology, Brigham and Women’s Hospital, Harvard Institute of Medicine, Room 945, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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Beth Stevens

2Harvard Medical School, Boston, MA 02115, USA.

3Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Center for Life Sciences, 12th Floor, 300 Longwood Avenue, Boston, MA 02115, USA.

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Cynthia A. Lemere

1Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Building for Transformative Medicine, 9th Floor, 60 Fenwood Road, Boston, MA 02115, USA.

2Harvard Medical School, Boston, MA 02115, USA.

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ORCID record for Cynthia A. Lemere
For correspondence: clemere@bwh.harvard.edu

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Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

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