31 May 2017
Vol 9, Issue 392

About The Cover

Cover image expansion

ONLINE COVER An Inside View of Pain Treatment. In search of a new approach for the treatment of pain, Jensen et al. examined the role of neurokinin 1 receptor in the transmission of pain signals. After determining that neurokinin 1 undergoes endocytosis and that this process is required for pain signaling, the authors designed a drug (shown in green) that can get incorporated into the endosome (depicted as a white circle) and inhibit its target protein from within the endosome. [CREDIT: THAO P. DO/MESOSCOPE.ORG;NIGEL W. BUNNETT]