Contents
31 May 2017
Vol 9, Issue 392
Vol 9, Issue 392
Focus
- A trust approach for sharing research reagents
The core feature of trusts—holding property for the benefit of others—is well suited to constructing a research community that treats reagents as public goods.
Research Articles
- Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
Therapeutic targeting of the neurokinin 1 receptor in endosomes provides efficacious and prolonged pain relief.
- Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts
Radiation therapy enhances nanotherapeutic drug delivery in a tumor-associated macrophage–dependent fashion.
- Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant Aβ plaques.
- Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers
The combination of PARP and MEK inhibitors is effective against RAS and RAF mutant tumors.
Editors' Choice
- Rapamycin keeps the reproductive clock ticking
Two weeks of rapamycin administration in young and old female mice leads to long-term improvements in ovarian function and reproductive longevity.
- A new therapeutic target for myelofibrosis is cause for Gli
Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.
- Say good night to your pain
Sleep deprivation induces pain hypersensitivity that can be reversed by increasing alertness.
Erratum
About The Cover
ONLINE COVER An Inside View of Pain Treatment. In search of a new approach for the treatment of pain, Jensen et al. examined the role of neurokinin 1 receptor in the transmission of pain signals. After determining that neurokinin 1 undergoes endocytosis and that this process is required for pain signaling, the authors designed a drug (shown in green) that can get incorporated into the endosome (depicted as a white circle) and inhibit its target protein from within the endosome. [CREDIT: THAO P. DO/MESOSCOPE.ORG;NIGEL W. BUNNETT]