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Research ArticleCancer
Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
- Katherine S. Yang1,2,*,
- Hyungsoon Im1,2,*,
- Seonki Hong1,2,*,
- Ilaria Pergolini3,
- Andres Fernandez del Castillo1,
- Rui Wang4,5,
- Susan Clardy1,2,
- Chen-Han Huang1,2,
- Craig Pille1,6,
- Soldano Ferrone3,
- Robert Yang1,
- Cesar M. Castro1,7,
- Hakho Lee1,2,
- Carlos Fernandez del Castillo3,7 and
- Ralph Weissleder1,2,8,†
- 1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
- 3Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
- 4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
- 5Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
- 6Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.
- 7Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
- 8Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
- ↵†Corresponding author. Email: rweissleder{at}mgh.harvard.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 24 May 2017:
Vol. 9, Issue 391, eaal3226
DOI: 10.1126/scitranslmed.aal3226
Vol. 9, Issue 391, eaal3226
DOI: 10.1126/scitranslmed.aal3226
Katherine S. Yang
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Hyungsoon Im
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Seonki Hong
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ilaria Pergolini
Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Andres Fernandez del Castillo
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Rui Wang
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
Susan Clardy
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Chen-Han Huang
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Craig Pille
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.
Soldano Ferrone
Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Robert Yang
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Cesar M. Castro
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Hakho Lee
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
Carlos Fernandez del Castillo
Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
Ralph Weissleder
Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
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