Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Katherine S. Yang; Hyungsoon Im; Seonki Hong; Ilaria Pergolini; Andres Fernandez del Castillo; Rui Wang; Susan Clardy; Chen-Han Huang; Craig Pille; Soldano Ferrone; Robert Yang; Cesar M. Castro; Hakho Lee; Carlos Fernandez del Castillo; Ralph Weissleder

doi:10.1126/scitranslmed.aal3226

Research ArticleCancer

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

View ORCID ProfileKatherine S. Yang¹,²,*,
View ORCID ProfileHyungsoon Im¹,²,*,
View ORCID ProfileSeonki Hong¹,²,*,
Ilaria Pergolini³,
View ORCID ProfileAndres Fernandez del Castillo¹,
View ORCID ProfileRui Wang⁴,⁵,
Susan Clardy¹,²,
Chen-Han Huang¹,²,
View ORCID ProfileCraig Pille¹,⁶,
Soldano Ferrone³,
Robert Yang¹,
View ORCID ProfileCesar M. Castro¹,⁷,
Hakho Lee¹,²,
Carlos Fernandez del Castillo³,⁷ and
View ORCID ProfileRalph Weissleder¹,²,⁸,†

¹Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
²Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
³Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
⁴Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
⁵Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
⁶Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.
⁷Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
⁸Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

↵†Corresponding author. Email: rweissleder{at}mgh.harvard.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 24 May 2017:
Vol. 9, Issue 391, eaal3226
DOI: 10.1126/scitranslmed.aal3226

Katherine S. Yang

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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ORCID record for Katherine S. Yang

Hyungsoon Im

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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ORCID record for Hyungsoon Im

Seonki Hong

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Ilaria Pergolini

3Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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Andres Fernandez del Castillo

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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ORCID record for Andres Fernandez del Castillo

Rui Wang

4Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

5Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.

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ORCID record for Rui Wang

Susan Clardy

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Chen-Han Huang

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Craig Pille

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

6Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.

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Soldano Ferrone

3Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

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Robert Yang

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Cesar M. Castro

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

7Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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ORCID record for Cesar M. Castro

Hakho Lee

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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Carlos Fernandez del Castillo

3Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

7Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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Ralph Weissleder

1Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

2Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

8Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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ORCID record for Ralph Weissleder
For correspondence: rweissleder@mgh.harvard.edu

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Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

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