Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Katherine S. Yang; Hyungsoon Im; Seonki Hong; Ilaria Pergolini; Andres Fernandez del Castillo; Rui Wang; Susan Clardy; Chen-Han Huang; Craig Pille; Soldano Ferrone; Robert Yang; Cesar M. Castro; Hakho Lee; Carlos Fernandez del Castillo; Ralph Weissleder

doi:10.1126/scitranslmed.aal3226

Research ArticleCancer

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Katherine S. Yang¹,²,*,
Hyungsoon Im¹,²,*,
Seonki Hong¹,²,*,
Ilaria Pergolini³,
Andres Fernandez del Castillo¹,
Rui Wang⁴,⁵,
Susan Clardy¹,²,
Chen-Han Huang¹,²,
Craig Pille¹,⁶,
Soldano Ferrone³,
Robert Yang¹,
Cesar M. Castro¹,⁷,
Hakho Lee¹,²,
Carlos Fernandez del Castillo³,⁷ and
Ralph Weissleder¹,²,⁸,†

¹Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
²Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
³Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.
⁴Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
⁵Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
⁶Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.
⁷Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
⁸Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

↵†Corresponding author. Email: rweissleder{at}mgh.harvard.edu

↵* These authors contributed equally to this work.

See allHide authors and affiliations

Science Translational Medicine 24 May 2017:
Vol. 9, Issue 391, eaal3226
DOI: 10.1126/scitranslmed.aal3226

Katherine S. Yang

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Katherine S. Yang

Hyungsoon Im

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Hyungsoon Im

Seonki Hong

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Seonki Hong

Ilaria Pergolini

Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Andres Fernandez del Castillo

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Andres Fernandez del Castillo

Rui Wang

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Rui Wang

Susan Clardy

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chen-Han Huang

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Craig Pille

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Health Sciences, Northeastern University, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Craig Pille

Soldano Ferrone

Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Robert Yang

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Cesar M. Castro

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Cesar M. Castro

Hakho Lee

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Carlos Fernandez del Castillo

Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA.Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ralph Weissleder

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ralph Weissleder
For correspondence: rweissleder@mgh.harvard.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools