Research ArticleCancer

Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy

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Science Translational Medicine  24 May 2017:
Vol. 9, Issue 391, eaal3226
DOI: 10.1126/scitranslmed.aal3226

A signature achievement

Pancreatic ductal adenocarcinoma is one of the deadliest types of tumors, in part because it is usually detected at a late stage. To facilitate the diagnosis of this tumor, Yang et al. developed a multiplexed plasmonic assay to evaluate extracellular vesicles in patient plasma for protein markers associated with the presence of pancreatic cancer. The authors identified a five-marker signature that yielded the most accurate diagnosis. To test their assay, the researchers analyzed samples from patients with pancreatic cancer and other types of pancreatic disease, as well as healthy controls, and confirmed the accuracy of their signature in prospectively collected samples.