Bacterial colonization and succession in a newly opened hospital

Simon Lax; Naseer Sangwan; Daniel Smith; Peter Larsen; Kim M. Handley; Miles Richardson; Kristina Guyton; Monika Krezalek; Benjamin D. Shogan; Jennifer Defazio; Irma Flemming; Baddr Shakhsheer; Stephen Weber; Emily Landon; Sylvia Garcia-Houchins; Jeffrey Siegel; John Alverdy; Rob Knight; Brent Stephens; Jack A. Gilbert

doi:10.1126/scitranslmed.aah6500

Research ArticleMICROBIOTA

Bacterial colonization and succession in a newly opened hospital

Simon Lax¹,²,
Naseer Sangwan²,³,
View ORCID ProfileDaniel Smith⁴,
Peter Larsen²,
View ORCID ProfileKim M. Handley¹,*,
View ORCID ProfileMiles Richardson¹,
View ORCID ProfileKristina Guyton³,
View ORCID ProfileMonika Krezalek³,
View ORCID ProfileBenjamin D. Shogan³,†,
Jennifer Defazio³,
View ORCID ProfileIrma Flemming³,‡,
Baddr Shakhsheer³,
Stephen Weber⁵,
Emily Landon⁵,
Sylvia Garcia-Houchins⁵,
View ORCID ProfileJeffrey Siegel⁶,⁷,
John Alverdy³,
View ORCID ProfileRob Knight⁸,⁹,
Brent Stephens¹⁰ and
View ORCID ProfileJack A. Gilbert¹,²,³,§

¹Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.
²Division of Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.
³Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.
⁴Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
⁵Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
⁶Department of Civil Engineering, University of Toronto, 35 St. George Street, Toronto, Ontario M5S 1A4, Canada.
⁷Dalla Lana School of Public Health, University of Toronto, 223 College Street, Toronto, Ontario M5T 1R4, Canada.
⁸Department of Pediatrics, University of California, San Diego, San Diego, CA 92037, USA.
⁹Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA 92037, USA.
¹⁰Department of Civil, Architectural and Environmental Engineering, Illinois Institute of Technology, 3201 South Dearborn Street, Chicago, IL 60616, USA.

↵§Corresponding author. Email: gilbertjack{at}gmail.com

↵* Present address: School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
↵† Present address: Division of Colon and Rectal Surgery, Mayo Clinic, Rochester, MN 55905, USA.
↵‡ Present address: Division of Trauma and Critical Care, Vanderbilt University, Nashville, TN 37212, USA.

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Science Translational Medicine 24 May 2017:
Vol. 9, Issue 391, eaah6500
DOI: 10.1126/scitranslmed.aah6500

Simon Lax

1Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.

2Division of Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.

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Naseer Sangwan

2Division of Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Daniel Smith

4Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

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ORCID record for Daniel Smith

Peter Larsen

2Division of Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.

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Kim M. Handley

1Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.

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Miles Richardson

1Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.

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Kristina Guyton

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Monika Krezalek

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Benjamin D. Shogan

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Jennifer Defazio

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Irma Flemming

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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ORCID record for Irma Flemming

Baddr Shakhsheer

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Stephen Weber

5Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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Emily Landon

5Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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Sylvia Garcia-Houchins

5Department of Medicine, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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Jeffrey Siegel

6Department of Civil Engineering, University of Toronto, 35 St. George Street, Toronto, Ontario M5S 1A4, Canada.

7Dalla Lana School of Public Health, University of Toronto, 223 College Street, Toronto, Ontario M5T 1R4, Canada.

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John Alverdy

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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Rob Knight

8Department of Pediatrics, University of California, San Diego, San Diego, CA 92037, USA.

9Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA 92037, USA.

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Brent Stephens

10Department of Civil, Architectural and Environmental Engineering, Illinois Institute of Technology, 3201 South Dearborn Street, Chicago, IL 60616, USA.

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Jack A. Gilbert

1Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.

2Division of Biosciences, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA.

3Microbiome Center, Department of Surgery, University of Chicago, A27 South Maryland Avenue, Chicago, IL 60637, USA.

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For correspondence: gilbertjack@gmail.com

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