24 May 2017
Vol 9, Issue 391

About The Cover

Cover image expansion

ONLINE COVER No Escape for Brain Metastases. This image depicts the microenvironment of a breast cancer brain metastasis in a mouse model. The metastasis near the center of the image shows a collection of tortuous, irregular, and abnormally dilated blood vessels (superficial vessels, yellow; deeper vasculature, shades of red). By studying brain metastases and their microenvironment, Kodack et al. determined that the microenvironment directly contributed to drug resistance in metastatic breast cancer and identified a potential therapeutic strategy for treating these challenging tumors. [CREDIT: B. J. VAKOC, R. M. LANNING, A. S. NAM, R. K. JAIN/MGH]