Contents
24 May 2017
Vol 9, Issue 391
Vol 9, Issue 391
Research Articles
- The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
The brain microenvironment triggers HER3-dependent de novo resistance to therapies targeting PI3K or HER2 in HER2-positive and/or PIK3CA-mutant breast cancer cells.
- Bacterial colonization and succession in a newly opened hospital
Patients share their microbiota with their rooms and with nursing staff, and this shapes the microbial ecology of the hospital environment.
- Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy
A multiplexed plasmonic assay analyzes circulating tumor-derived extracellular vesicles for detection of pancreatic ductal adenocarcinoma.
Report
- The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS.
Technical Comments
- Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin”
Although the combination of decitabine and platinum drugs may be promising for therapy of renal cell carcinoma, the role of OCT2 needs further investigations.
- Response to Comment on “Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin”
OCT2 plays a key role in synergy between decitabine and oxaliplatin in renal cell carcinoma cell lines.
Editors' Choice
- Nanomedicine goes to school
Integration of engineering and immunological tools proposes design guidelines for nanoparticles that direct T cells toward specific phenotypes to control autoimmune disease.
- Dive deep, stay focused!
Noninvasive ultra-broadband optoacoustic mesoscopy skin imaging technology may provide objective assessment of skin disease.
- Stable hormones for stable moods
The rise in ovarian hormones triggers premenstrual dysphoric disorder symptoms in women.
- A GEMA of a personalized medicine strategy
A screening method can identify tumors susceptible to synthetic lethality via PARP inhibition.
About The Cover
ONLINE COVER No Escape for Brain Metastases. This image depicts the microenvironment of a breast cancer brain metastasis in a mouse model. The metastasis near the center of the image shows a collection of tortuous, irregular, and abnormally dilated blood vessels (superficial vessels, yellow; deeper vasculature, shades of red). By studying brain metastases and their microenvironment, Kodack et al. determined that the microenvironment directly contributed to drug resistance in metastatic breast cancer and identified a potential therapeutic strategy for treating these challenging tumors. [CREDIT: B. J. VAKOC, R. M. LANNING, A. S. NAM, R. K. JAIN/MGH]