10 May 2017
Vol 9, Issue 389

About The Cover

Cover image expansion

ONLINE COVER Cellular Thievery. Antibodies against immune checkpoint proteins such as PD-1 keep antitumor T cells from becoming exhausted and can greatly improve the survival of cancer patients, but even this therapy is not always effective, and a paper by Arlauckas et al. demonstrates one reason why. Using intravital imaging to track individual cells and antibodies, the authors observed macrophages removing anti–PD-1 antibodies from T cells, thus inactivating them. This image shows an example of this interaction, with a macrophage (red) directly contacting T cells (blue) and removing the anti–PD-1 antibody (yellow). [CREDIT: JONATHAN C. CARLSON, SEAN P. ARLAUCKAS/MGH CENTER FOR SYSTEMS BIOLOGY]