A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants

Qing Zhu; Jason S. McLellan; Nicole L. Kallewaard; Nancy D. Ulbrandt; Susan Palaszynski; Jing Zhang; Brian Moldt; Anis Khan; Catherine Svabek; Josephine M. McAuliffe; Daniel Wrapp; Nita K. Patel; Kimberly E. Cook; Bettina W. M. Richter; Patricia C. Ryan; Andy Q. Yuan; JoAnn A. Suzich

doi:10.1126/scitranslmed.aaj1928

Research ArticleInfectious Disease

A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants

View ORCID ProfileQing Zhu¹,*,†,
View ORCID ProfileJason S. McLellan²,†,
View ORCID ProfileNicole L. Kallewaard¹,
View ORCID ProfileNancy D. Ulbrandt¹,
Susan Palaszynski¹,
Jing Zhang¹,
Brian Moldt¹,
Anis Khan³,
View ORCID ProfileCatherine Svabek¹,
View ORCID ProfileJosephine M. McAuliffe¹,
Daniel Wrapp²,
View ORCID ProfileNita K. Patel¹,
Kimberly E. Cook⁴,
Bettina W. M. Richter¹,
Patricia C. Ryan⁵,
View ORCID ProfileAndy Q. Yuan⁴ and
View ORCID ProfileJoAnn A. Suzich¹,*

¹Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
²Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, 7200 Vail Building, Hanover, NH 03755, USA.
³Department of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
⁴Department of Antibody Discovery and Protein Engineering, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.
⁵Biologics Safety Assessment, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

↵*Corresponding author. Email: suzichj{at}medimmune.com (J.A.S.); zhuq{at}medimmune.com (Q.Z.)

↵† These authors contributed equally to this work.

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Science Translational Medicine 03 May 2017:
Vol. 9, Issue 388, eaaj1928
DOI: 10.1126/scitranslmed.aaj1928

Qing Zhu

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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ORCID record for Qing Zhu
For correspondence: suzichj@medimmune.com zhuq@medimmune.com

Jason S. McLellan

2Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, 7200 Vail Building, Hanover, NH 03755, USA.

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ORCID record for Jason S. McLellan

Nicole L. Kallewaard

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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ORCID record for Nicole L. Kallewaard

Nancy D. Ulbrandt

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Susan Palaszynski

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Jing Zhang

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Brian Moldt

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Anis Khan

3Department of Clinical Pharmacology and Drug Metabolism and Pharmacokinetics, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Catherine Svabek

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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ORCID record for Catherine Svabek

Josephine M. McAuliffe

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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ORCID record for Josephine M. McAuliffe

Daniel Wrapp

2Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, 7200 Vail Building, Hanover, NH 03755, USA.

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Nita K. Patel

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Kimberly E. Cook

4Department of Antibody Discovery and Protein Engineering, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Bettina W. M. Richter

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Patricia C. Ryan

5Biologics Safety Assessment, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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Andy Q. Yuan

4Department of Antibody Discovery and Protein Engineering, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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ORCID record for Andy Q. Yuan

JoAnn A. Suzich

1Department of Infectious Disease, MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878, USA.

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ORCID record for JoAnn A. Suzich
For correspondence: suzichj@medimmune.com zhuq@medimmune.com

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A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants

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