Research ArticleMalaria

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

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Science Translational Medicine  26 Apr 2017:
Vol. 9, Issue 387, eaad9735
DOI: 10.1126/scitranslmed.aad9735

Article Information

vol. 9 no. 387

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 1, 2015
  • Accepted for publication November 21, 2016
  • .

Author Information

  1. Tanya Paquet1,
  2. Claire Le Manach1,
  3. Diego González Cabrera1,
  4. Yassir Younis1,
  5. Philipp P. Henrich2,3,
  6. Tara S. Abraham2,4,
  7. Marcus C. S. Lee2,5,
  8. Rajshekhar Basak2,6,
  9. Sonja Ghidelli-Disse7,
  10. María José Lafuente-Monasterio8,
  11. Marcus Bantscheff7,
  12. Andrea Ruecker9,
  13. Andrew M. Blagborough9,
  14. Sara E. Zakutansky9,
  15. Anne-Marie Zeeman10,
  16. Karen L. White11,
  17. David M. Shackleford11,
  18. Janne Mannila11,12,
  19. Julia Morizzi11,
  20. Christian Scheurer13,14,
  21. Iñigo Angulo-Barturen8,
  22. María Santos Martínez8,
  23. Santiago Ferrer8,
  24. Laura María Sanz8,
  25. Francisco Javier Gamo8,
  26. Janette Reader15,
  27. Mariette Botha15,
  28. Koen J. Dechering16,
  29. Robert W. Sauerwein16,17,
  30. Anchalee Tungtaeng18,
  31. Pattaraporn Vanachayangkul19,
  32. Chek Shik Lim20,
  33. Jeremy Burrows21,
  34. Michael J. Witty1,21,
  35. Kennan C. Marsh22,
  36. Christophe Bodenreider20,
  37. Rosemary Rochford23,
  38. Suresh M. Solapure24,
  39. María Belén Jiménez-Díaz4,
  40. Sergio Wittlin13,14,
  41. Susan A. Charman11,
  42. Cristina Donini21,
  43. Brice Campo21,
  44. Lyn-Marie Birkholtz15,
  45. Kirsten K. Hanson25,
  46. Gerard Drewes7,
  47. Clemens H. M. Kocken10,
  48. Michael J. Delves9,
  49. Didier Leroy21,
  50. David A. Fidock2,26,
  51. David Waterson1,21,
  52. Leslie J. Street1 and
  53. Kelly Chibale1,27,*
  1. 1Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  2. 2Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
  3. 3The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
  4. 4Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, 1020 Locust Street, Suite 368, Philadelphia, PA 19107, USA.
  5. 5Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
  6. 6Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520–8114, USA.
  7. 7Cellzome GmbH, Molecular Discovery Research, GlaxoSmithKline, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
  8. 8Malaria Disease Performance Unit, Tres Cantos Medicines Development Campus, Diseases of the Developing World, GlaxoSmithKline, Severo Ochoa 2, 28760 Tres Cantos, Madrid, Spain.
  9. 9Department of Life Sciences, Imperial College, London SW7 2AZ, UK.
  10. 10Department of Parasitology, Biomedical Primate Research Centre, 2280 GH Rijswijk, Netherlands.
  11. 11Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
  12. 12Admescope Ltd., Typpitie 1, 90620 Oulu, Finland.
  13. 13Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.
  14. 14University of Basel, 4003 Basel, Switzerland.
  15. 15Department of Biochemistry, Centre for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
  16. 16TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, Netherlands.
  17. 17Radboud University Medical Center, Department of Medical Microbiology, 6500 HB Nijmegen, Netherlands.
  18. 18Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  19. 19Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.
  20. 20Novartis Institute for Tropical Diseases Pte. Ltd., 10 Biopolis Road, #05-01 Chromos, Singapore 138670, Singapore.
  21. 21Medicines for Malaria Venture, International Center Cointrin, Route de Pré-Bois 20, 1215 Geneva, Switzerland.
  22. 22AbbVie, 1 North Waukegan Road, North Chicago, IL 60064-6104, USA.
  23. 23Departments of Immunology and Microbiology and Environmental and Occupational Health, University of Colorado Denver, Aurora, CO 80045, USA.
  24. 24Nagarjuna Gardens, 60 Feet Road, Sahakaranagar, Bangalore 560092, India.
  25. 25Department of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX 78249, USA.
  26. 26Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  27. 27South African Medical Research Council Drug Discovery and Development Research Unit, and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.
  1. *Corresponding author. Email: kelly.chibale{at}uct.ac.za

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