26 April 2017
Vol 9, Issue 387
  • Focus

  • Research Articles

    • Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice

      Optogenetically engineered cells maintain blood glucose homeostasis in mice by semiautonomous, wirelessly regulated exposure to far-red light.

    • Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

      MMV390048, a member of a new class of inhibitors of the Plasmodium phosphatidylinositol 4-kinase, shows potential for both treatment and prophylaxis.

    • Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion

      The concomitant use of CDK4/6 inhibitors with cytotoxic agents may prevent chemotherapy-induced bone marrow exhaustion in cancer patients.

  • Editors' Choice

About The Cover

Cover image expansion

ONLINE COVER Wireless Glucose Control. This image shows a dish containing a hydrogel capsule (pink oval) with embedded light-emitting diodes (LEDs). Shao et al. added engineered cells to LED-laden hydrogels and implanted these capsules into diabetic mice. Mice were placed within an electromagnetic field generator (copper wire) that was turned off and on using a smartphone app. The field generator controlled the intensity and duration of far-red light produced by the LEDs. In response to light, the engineered cells secreted glucose-lowering hormones to regulate glucose. This smartphone-controlled system blends synthetic biology and optogenetics to offer a wireless way to manage diabetes in mice. [CREDIT: HAIFENG YE/EAST CHINA NORMAL UNIVERSITY]