26 April 2017
Vol 9, Issue 387

About The Cover

Cover image expansion

ONLINE COVER Wireless Glucose Control. This image shows a dish containing a hydrogel capsule (pink oval) with embedded light-emitting diodes (LEDs). Shao et al. added engineered cells to LED-laden hydrogels and implanted these capsules into diabetic mice. Mice were placed within an electromagnetic field generator (copper wire) that was turned off and on using a smartphone app. The field generator controlled the intensity and duration of far-red light produced by the LEDs. In response to light, the engineered cells secreted glucose-lowering hormones to regulate glucose. This smartphone-controlled system blends synthetic biology and optogenetics to offer a wireless way to manage diabetes in mice. [CREDIT: HAIFENG YE/EAST CHINA NORMAL UNIVERSITY]