Contents
26 April 2017
Vol 9, Issue 387
Vol 9, Issue 387
Focus
- Photoactivated cells link diagnosis and therapy
A semiautonomous system enables implanted photoactivated cells to produce glucose-lowering hormones and maintain glucose homeostasis in diabetic mice (Shao et al., this issue).
Research Articles
- Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice
Optogenetically engineered cells maintain blood glucose homeostasis in mice by semiautonomous, wirelessly regulated exposure to far-red light.
- Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow
Bone clearing and light-sheet microscopy enables visualization and quantification of fluorescent single cells in intact bone.
- Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
MMV390048, a member of a new class of inhibitors of the Plasmodium phosphatidylinositol 4-kinase, shows potential for both treatment and prophylaxis.
- Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion
The concomitant use of CDK4/6 inhibitors with cytotoxic agents may prevent chemotherapy-induced bone marrow exhaustion in cancer patients.
Editors' Choice
- What’s old is new again: Autologous stem cell transplant for AMD
Transplanted RPE cells derived from induced pluripotent stem cells maintained vision and were well tolerated in a patient with age-related macular degeneration.
- Nanoparticles improve economic mileage for CARs
Targeted nanoparticles deliver chimeric antigen receptor genes to T cells in situ.
- Defeating Zika
A live attenuated Zika virus vaccine produces sterilizing immunity in mice.
- The antisocial side of antibiotics
Perinatal exposure to penicillin may result in long-lasting gut and behavioral changes.
About The Cover
ONLINE COVER Wireless Glucose Control. This image shows a dish containing a hydrogel capsule (pink oval) with embedded light-emitting diodes (LEDs). Shao et al. added engineered cells to LED-laden hydrogels and implanted these capsules into diabetic mice. Mice were placed within an electromagnetic field generator (copper wire) that was turned off and on using a smartphone app. The field generator controlled the intensity and duration of far-red light produced by the LEDs. In response to light, the engineered cells secreted glucose-lowering hormones to regulate glucose. This smartphone-controlled system blends synthetic biology and optogenetics to offer a wireless way to manage diabetes in mice. [CREDIT: HAIFENG YE/EAST CHINA NORMAL UNIVERSITY]