Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Kiran Yanamandra; Tirth K. Patel; Hong Jiang; Suzanne Schindler; Jason D. Ulrich; Adam L. Boxer; Bruce L. Miller; Diana R. Kerwin; Gilbert Gallardo; Floy Stewart; Mary Beth Finn; Nigel J. Cairns; Philip B. Verghese; Ilana Fogelman; Tim West; Joel Braunstein; Grace Robinson; Jennifer Keyser; Joseph Roh; Stephanie S. Knapik; Yan Hu; David M. Holtzman

doi:10.1126/scitranslmed.aal2029

Research ArticleTAUOPATHIES

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

Kiran Yanamandra¹,²,*,
Tirth K. Patel¹,*,
Hong Jiang¹,
Suzanne Schindler¹,
Jason D. Ulrich¹,
Adam L. Boxer³,
Bruce L. Miller³,
Diana R. Kerwin⁴,
Gilbert Gallardo¹,
Floy Stewart¹,
Mary Beth Finn¹,
Nigel J. Cairns¹,
Philip B. Verghese⁵,
Ilana Fogelman⁵,
Tim West⁵,
Joel Braunstein⁵,
Grace Robinson¹,
Jennifer Keyser¹,
Joseph Roh¹,
Stephanie S. Knapik⁵,
Yan Hu⁵ and
David M. Holtzman¹,†

¹Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
²AbbVie Inc. Foundational Neuroscience Center, Cambridge, MA 02139, USA.
³Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
⁴Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA.
⁵C₂N Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

↵†Corresponding author. Email: holtzman{at}neuro.wustl.edu

↵* These authors contributed equally to this work.

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Science Translational Medicine 19 Apr 2017:
Vol. 9, Issue 386, eaal2029
DOI: 10.1126/scitranslmed.aal2029

Kiran Yanamandra

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

2AbbVie Inc. Foundational Neuroscience Center, Cambridge, MA 02139, USA.

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Tirth K. Patel

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Hong Jiang

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Suzanne Schindler

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Jason D. Ulrich

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Adam L. Boxer

3Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.

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Bruce L. Miller

3Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.

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Diana R. Kerwin

4Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA.

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Gilbert Gallardo

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Floy Stewart

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Mary Beth Finn

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Nigel J. Cairns

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Philip B. Verghese

5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

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Ilana Fogelman

5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

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Tim West

5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

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Joel Braunstein

5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

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Grace Robinson

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Jennifer Keyser

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Joseph Roh

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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Stephanie S. Knapik

5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

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Yan Hu

5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.

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David M. Holtzman

1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.

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For correspondence: holtzman@neuro.wustl.edu

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Administration of an anti-tau antibody to transgenic mice expressing human tau and to patients with tauopathy increased the concentration of tau in plasma.

Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy

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