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Research ArticleTAUOPATHIES
Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
- Kiran Yanamandra1,2,*,
- Tirth K. Patel1,*,
- Hong Jiang1,
- Suzanne Schindler1,
- Jason D. Ulrich1,
- Adam L. Boxer3,
- Bruce L. Miller3,
- Diana R. Kerwin4,
- Gilbert Gallardo1,
- Floy Stewart1,
- Mary Beth Finn1,
- Nigel J. Cairns1,
- Philip B. Verghese5,
- Ilana Fogelman5,
- Tim West5,
- Joel Braunstein5,
- Grace Robinson1,
- Jennifer Keyser1,
- Joseph Roh1,
- Stephanie S. Knapik5,
- Yan Hu5 and
- David M. Holtzman1,†
- 1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
- 2AbbVie Inc. Foundational Neuroscience Center, Cambridge, MA 02139, USA.
- 3Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
- 4Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA.
- 5C2N Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
- ↵†Corresponding author. Email: holtzman{at}neuro.wustl.edu
↵* These authors contributed equally to this work.
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Science Translational Medicine 19 Apr 2017:
Vol. 9, Issue 386, eaal2029
DOI: 10.1126/scitranslmed.aal2029
Vol. 9, Issue 386, eaal2029
DOI: 10.1126/scitranslmed.aal2029
Kiran Yanamandra
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
2AbbVie Inc. Foundational Neuroscience Center, Cambridge, MA 02139, USA.
Tirth K. Patel
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Hong Jiang
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Suzanne Schindler
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Jason D. Ulrich
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Adam L. Boxer
3Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Bruce L. Miller
3Clinical Trials Program, Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Diana R. Kerwin
4Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA.
Gilbert Gallardo
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Floy Stewart
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Mary Beth Finn
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Nigel J. Cairns
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Philip B. Verghese
5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
Ilana Fogelman
5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
Tim West
5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
Joel Braunstein
5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
Grace Robinson
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Jennifer Keyser
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Joseph Roh
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
Stephanie S. Knapik
5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
Yan Hu
5CN Diagnostics, Center for Emerging Technologies, 4041 Forest Park Avenue, St. Louis, MO 63108, USA.
David M. Holtzman
1Hope Center for Neurological Disorders and Knight Alzheimer’s Disease Research Center, Department of Neurology, Washington University, St. Louis, MO 63110,USA.
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