19 April 2017
Vol 9, Issue 386

About The Cover

Cover image expansion

ONLINE COVER Heparin Hydrogel Helps Heal Wounds. Inflammatory chemokines contribute to poor wound healing. To improve wound healing, Lohmann et al. devised a hydrogel material that scavenges chemokines. This image shows the heparin (yellow) glycosaminoglycan-modified hydrogel (gray network) applied to a skin wound, where it sequesters chemokines (red) secreted by an immune cell (white and purple). The hydrogel captured inflammatory chemokines—but not growth factors beneficial for wound healing—from wound fluids isolated from human venous leg ulcers. In a mouse model of delayed skin wound healing, the hydrogel reduced inflammation and hastened tissue formation, revascularization, and wound closure. These results suggest capturing chemokines could help chronic wounds heal. [CREDIT: ZOLTÁN TANCZIK/VOR WERBEAGENTUR GMBH AND LUCAS SCHIRMER, UWE FREUDENBERG, CARSTEN WERNER/LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN]