Contents
19 April 2017
Vol 9, Issue 386
Vol 9, Issue 386
Perspective
- Clinical chemoproteomics—Opportunities and obstacles
The prospects for applying chemoproteomics in the clinical setting are discussed.
Research Articles
- Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice
Glycosaminoglycan-based hydrogels scavenge proinflammatory chemokines, reduce the influx of immune cells, and improve the healing of chronic wounds.
- Improving genetic diagnosis in Mendelian disease with transcriptome sequencing
Transcriptome sequencing improves the diagnostic rate for Mendelian disease in patients for whom genetic analysis has not returned a diagnosis.
- RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury
Activation of the RIG-I or STING pathways results in a type I interferon response that protects gut integrity after irradiation- or immune-induced tissue injury.
- Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
Administration of an anti-tau antibody to transgenic mice expressing human tau and to patients with tauopathy increased the concentration of tau in plasma.
Editors' Choice
- Toward off-the-shelf adoptive T cell therapies
Artificial thymic organoids may enable more efficient engineered T cell production for immunotherapy.
- A paternal diet for offspring success?
Supplementation of the diet of male mice with methyl donors, such as methionine and folic acid, prior to mating impaired learning, memory, and metabolic functions in the offspring.
- Combination of an oncolytic virus with PD-L1 blockade keeps cancer in check
An oncolytic vaccinia virus expressing CXCL11 combined with PD-L1 blockade significantly reduces tumor burden and improves survival in murine cancer models.
- Filtering more than light in the developing retina
Restricting transcytosis is essential for blood-retinal barrier formation.
About The Cover
ONLINE COVER Heparin Hydrogel Helps Heal Wounds. Inflammatory chemokines contribute to poor wound healing. To improve wound healing, Lohmann et al. devised a hydrogel material that scavenges chemokines. This image shows the heparin (yellow) glycosaminoglycan-modified hydrogel (gray network) applied to a skin wound, where it sequesters chemokines (red) secreted by an immune cell (white and purple). The hydrogel captured inflammatory chemokines—but not growth factors beneficial for wound healing—from wound fluids isolated from human venous leg ulcers. In a mouse model of delayed skin wound healing, the hydrogel reduced inflammation and hastened tissue formation, revascularization, and wound closure. These results suggest capturing chemokines could help chronic wounds heal. [CREDIT: ZOLTÁN TANCZIK/VOR WERBEAGENTUR GMBH AND LUCAS SCHIRMER, UWE FREUDENBERG, CARSTEN WERNER/LEIBNIZ INSTITUTE OF POLYMER RESEARCH DRESDEN]