Research ArticleCancer

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

See allHide authors and affiliations

Science Translational Medicine  05 Apr 2017:
Vol. 9, Issue 384, eaai8504
DOI: 10.1126/scitranslmed.aai8504

Article Information

vol. 9 no. 384

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication September 6, 2016
  • Resubmitted December 21, 2016
  • Accepted for publication March 4, 2017
  • .

Author Information

  1. Claire Vennin1,2,*,
  2. Venessa T. Chin1,2,*,
  3. Sean C. Warren1,2,,
  4. Morghan C. Lucas1,2,,
  5. David Herrmann1,2,
  6. Astrid Magenau1,2,
  7. Pauline Melenec1,2,
  8. Stacey N. Walters1,2,
  9. Gonzalo del Monte-Nieto2,3,
  10. James R. W. Conway1,2,
  11. Max Nobis1,2,
  12. Amr H. Allam1,2,
  13. Rachael A. McCloy1,2,
  14. Nicola Currey1,2,
  15. Mark Pinese1,2,
  16. Alice Boulghourjian1,
  17. Anaiis Zaratzian1,
  18. Arne A. S. Adam3,
  19. Celine Heu4,
  20. Adnan M. Nagrial1,
  21. Angela Chou1,2,5,
  22. Angela Steinmann1,
  23. Alison Drury1,
  24. Danielle Froio1,
  25. Marc Giry-Laterriere1,2,
  26. Nathanial L. E. Harris1,6,
  27. Tri Phan1,2,
  28. Rohit Jain7,8,
  29. Wolfgang Weninger7,8,9,
  30. Ewan J. McGhee10,
  31. Renee Whan3,
  32. Amber L. Johns1,11,12,13,
  33. Jaswinder S. Samra10,13,14,
  34. Lorraine Chantrill1,13,14,
  35. Anthony J. Gill1,11,12,13,15,
  36. Maija Kohonen-Corish1,2,16,
  37. Richard P. Harvey2,3,17,
  38. Andrew V. Biankin13,18,19,
  39. Australian Pancreatic Cancer Genome Initiative (APGI)13,
  40. T. R. Jeffry Evans10,
  41. Kurt I. Anderson10,
  42. Shane T. Grey1,2,
  43. Christopher J. Ormandy1,2,
  44. David Gallego-Ortega1,2,
  45. Yingxiao Wang20,
  46. Michael S. Samuel21,
  47. Owen J. Sansom10,
  48. Andrew Burgess1,2,
  49. Thomas R. Cox1,2,
  50. Jennifer P. Morton10,
  51. Marina Pajic1,2,*, and
  52. Paul Timpson1,2,*,
  1. 1The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.
  2. 2St. Vincent’s Clinical School, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2010, Australia.
  3. 3Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, New South Wales 2010, Australia.
  4. 4Biomedical Imaging Facility, Mark Wainwright Analytical Centre, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.
  5. 5Department of Pathology, St. Vincent’s Hospital, Sydney, New South Wales 2010, Australia.
  6. 6Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales 2522, Australia.
  7. 7Immune Imaging Program, Centenary Institute, University of Sydney, Sydney, New South Wales 2006, Australia.
  8. 8University of Sydney Medical School, Sydney, New South Wales 2006, Australia.
  9. 9Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
  10. 10Cancer Research UK Beatson Institute, Glasgow, Scotland G61 BD, U.K.
  11. 11Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research and Royal North Shore Hospital, Sydney, New South Wales 2065, Australia.
  12. 12University of Sydney, Sydney, New South Wales 2006, Australia.
  13. 13Australian Pancreatic Cancer Genome Initiative
  14. 14Department of Surgery, Royal North Shore Hospital, Sydney, New South Wales 2065, Australia.
  15. 15Macarthur Cancer Therapy Centre, Campbelltown Hospital, Sydney, New South Wales 2560, Australia.
  16. 16School of Medicine, Western Sydney University, Penrith, Sydney, New South Wales 2751, Australia.
  17. 17School of Biotechnology and Biomolecular Science, University of New South Wales, Sydney, New South Wales 2052, Australia.
  18. 18Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Scotland G61 BD, U.K.
  19. 19West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Scotland G61 BD, U.K.
  20. 20Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, San Diego, CA 92121, USA.
  21. 21Centre for Cancer Biology, SA Pathology and University of South Australia School of Medicine, University of Adelaide, Adelaide, South Australia 5000, Australia.
  1. Corresponding author. Email: m.pajic{at}garvan.org.au (M. Pajic); p.timpson{at}garvan.org.au (P.T.)
    • * These authors contributed equally to this work.

    • These authors contributed equally to this work.

    Altmetric

    Article usage

    Article usage: April 2017 to August 2019

    AbstractFullPdf
    Apr 20178127486996
    May 20171134129241
    Jun 2017593117176
    Jul 201774295101
    Aug 20175976790
    Sep 20175986472
    Oct 20173914583
    Nov 20174425289
    Dec 20174084262
    Jan 20184605277
    Feb 20183542654
    Mar 20182832455
    Apr 20183354052
    May 20183974447
    Jun 20182512855
    Jul 20182063758
    Aug 20181617553
    Sep 20181744656
    Oct 20181716456
    Nov 20182075368
    Dec 20181923652
    Jan 20191785055
    Feb 20191515655
    Mar 20191796254
    Apr 20191594551
    May 20191364731
    Jun 20191343832
    Jul 20191627241
    Aug 2019372419