05 April 2017
Vol 9, Issue 384
  • Research Articles

    • Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

      Fine-tuned manipulation of tumor tension and vasculature enhances response to chemotherapy and impairs metastatic spread in pancreatic cancer.

    • Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

      Positron emission tomography with a probe targeting type I collagen enables detection, staging, and treatment response monitoring in lung fibrosis.

    • Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody

      A single mAb is an effective therapy in nonhuman primates infected with Marburg or Ravn virus.

    • Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

      Functional synergism and inhibitory effects of chemokine heterodimers can be selectively targeted by specific peptides in models of inflammation.

  • Editors' Choice

    • Clocks stop sugar shock

      The circadian clock orchestrates the timing of insulin and glucagon secretion, which is important for glycemic control.

    • Double trouble for CML

      Combining two BCR-ABL1 inhibitors with nonoverlapping mechanisms of action eradicates CML and prevents recurrence.

    • Worth its salt

      Angiotensin type 1 receptors are required for leptin-mediated control of resting metabolic rate but not blood pressure.

About The Cover

Cover image expansion

ONLINE COVER Priming for Chemotherapy Success. Pancreatic cancer is notorious for its treatment resistance, in part because of its dense stroma, which is difficult for chemotherapy drugs to penetrate. Vennin et al. showed that "priming" pancreatic tumors by disrupting their stroma is an effective way to increase drug penetration and improve the success rate of chemotherapy in mouse models of this disease. This cover image depicts quantum dots (red) coursing through a blood vessel surrounded by a dense matrix of collagen (blue). The authors used similar experiments with quantum dots to compare the leakiness of tumor blood vessels before and after treatment with Fasudil. [CREDIT: TIMPSON LABORATORY, GARVAN INSTITUTE OF MEDICAL RESEARCH]