Contents
29 March 2017
Vol 9, Issue 383
Vol 9, Issue 383
Perspective
- Cardiac regeneration: All work and no repair?
Cardiac development may contribute to loss of regenerative capacity in the adult mammalian heart.
Research Articles
- Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis
Poly(GP) proteins are a promising pharmacodynamic marker for developing and testing therapeutics for treating C9ORF72-associated amyotrophic lateral sclerosis.
- Using geospatial mapping to design HIV elimination strategies for sub-Saharan Africa
Mapping the geographic dispersion pattern of HIV-infected individuals in a sub-Saharan African country reveals the challenge to eliminating HIV.
- The druggable genome and support for target identification and validation in drug development
The druggable genome and genome-wide association study data reveal new drug development and repurposing opportunities.
Report
- Estimation of polio infection prevalence from environmental surveillance data
Close monitoring of virus shed into sewage systems allows quantitative surveillance of a polio outbreak.
Editors' Choice
- Target practice in severe asthma
The NLRP3 inflammasome/caspase-1/IL-1β axis may be a therapeutic target in severe steroid-resistant asthma.
- The neural substrates of super memory
Specific neural networks support superior memory in world-class memory athletes.
- Macrophages take rheumatoid arthritis up a “Notch”
Notch signaling in bone marrow–derived inflammatory macrophages is central to synovial inflammation seen in rheumatoid arthritis, representing a promising future therapeutic target.
- How to straighten out that which bends up
Chikungunya virus requires host granzyme A to drive joint inflammation.
About The Cover
ONLINE COVER A Home Run for ALS Research. Amyotrophic lateral sclerosis (ALS), a devastating disease involving progressive motor neuron degeneration, is also called Lou Gehrig's disease after the baseball star (pictured) who died of the illness in 1941. The most common cause of ALS is repeat expansion mutations in the C9ORF72 gene leading to accumulation of G4C2 RNAs and the poly(GP) proteins they encode. Poly(GP) proteins can be detected in the cerebrospinal fluid of ALS patients carrying C9ORF72 mutations and may be a useful pharmacodynamic marker for testing the efficacy of RNA therapies that are entering clinical trials (Gendron et al.). [CREDIT: LOUIS VAN OEYEN/WRHS/CONTRIBUTOR]
