29 March 2017
Vol 9, Issue 383

About The Cover

Cover image expansion

ONLINE COVER A Home Run for ALS Research. Amyotrophic lateral sclerosis (ALS), a devastating disease involving progressive motor neuron degeneration, is also called Lou Gehrig's disease after the baseball star (pictured) who died of the illness in 1941. The most common cause of ALS is repeat expansion mutations in the C9ORF72 gene leading to accumulation of G4C2 RNAs and the poly(GP) proteins they encode. Poly(GP) proteins can be detected in the cerebrospinal fluid of ALS patients carrying C9ORF72 mutations and may be a useful pharmacodynamic marker for testing the efficacy of RNA therapies that are entering clinical trials (Gendron et al.). [CREDIT: LOUIS VAN OEYEN/WRHS/CONTRIBUTOR]