Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections

Henry L. Schreiber; Matt S. Conover; Wen-Chi Chou; Michael E. Hibbing; Abigail L. Manson; Karen W. Dodson; Thomas J. Hannan; Pacita L. Roberts; Ann E. Stapleton; Thomas M. Hooton; Jonathan Livny; Ashlee M. Earl; Scott J. Hultgren

doi:10.1126/scitranslmed.aaf1283

Research ArticleInfectious Disease

Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections

View ORCID ProfileHenry L. Schreiber IV¹,²,
View ORCID ProfileMatt S. Conover¹,
View ORCID ProfileWen-Chi Chou²,
View ORCID ProfileMichael E. Hibbing¹,
View ORCID ProfileAbigail L. Manson²,
Karen W. Dodson¹,
View ORCID ProfileThomas J. Hannan³,
Pacita L. Roberts⁴,
View ORCID ProfileAnn E. Stapleton⁴,
View ORCID ProfileThomas M. Hooton⁵,
View ORCID ProfileJonathan Livny²,*,
View ORCID ProfileAshlee M. Earl²,* and
View ORCID ProfileScott J. Hultgren¹,⁶,*

¹Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.
²Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
³Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.
⁴Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
⁵Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
⁶Center for Women’s Infectious Disease Research, Washington University, St. Louis, MO 63110, USA.

↵*Corresponding author. Email: livny{at}broadinstitute.org (J.L.); aearl{at}broadinstitute.org (A.M.E.); hultgren{at}wusm.wustl.edu (S.J.H.)

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Science Translational Medicine 22 Mar 2017:
Vol. 9, Issue 382, eaaf1283
DOI: 10.1126/scitranslmed.aaf1283

Henry L. Schreiber IV

1Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.

2Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

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Matt S. Conover

1Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.

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Wen-Chi Chou

2Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

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Michael E. Hibbing

1Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.

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Abigail L. Manson

2Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

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Karen W. Dodson

1Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.

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Thomas J. Hannan

3Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.

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Pacita L. Roberts

4Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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Ann E. Stapleton

4Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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Thomas M. Hooton

5Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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Jonathan Livny

2Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

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For correspondence: livny@broadinstitute.org aearl@broadinstitute.org hultgren@wusm.wustl.edu

Ashlee M. Earl

2Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.

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For correspondence: livny@broadinstitute.org aearl@broadinstitute.org hultgren@wusm.wustl.edu

Scott J. Hultgren

1Department of Molecular Microbiology, Washington University, St. Louis, MO 63110, USA.

6Center for Women’s Infectious Disease Research, Washington University, St. Louis, MO 63110, USA.

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For correspondence: livny@broadinstitute.org aearl@broadinstitute.org hultgren@wusm.wustl.edu

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Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections

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