Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

S. Munir Alam; Baptiste Aussedat; Yusuf Vohra; R. Ryan Meyerhoff; Evan M. Cale; William E. Walkowicz; Nathan A. Radakovich; Kara Anasti; Lawrence Armand; Robert Parks; Laura Sutherland; Richard Scearce; M. Gordon Joyce; Marie Pancera; Aliaksandr Druz; Ivelin S. Georgiev; Tarra Von Holle; Amanda Eaton; Christopher Fox; Steven G. Reed; Mark Louder; Robert T. Bailer; Lynn Morris; Salim S. Abdool-Karim; Myron Cohen; Hua-Xin Liao; David C. Montefiori; Peter K. Park; Alberto Fernández-Tejada; Kevin Wiehe; Sampa Santra; Thomas B. Kepler; Kevin O. Saunders; Joseph Sodroski; Peter D. Kwong; John R. Mascola; Mattia Bonsignori; M. Anthony Moody; Samuel Danishefsky; Barton F. Haynes

doi:10.1126/scitranslmed.aai7521

Research ArticleHIV

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

S. Munir Alam¹,²,³,*,†,
Baptiste Aussedat⁴,†,
Yusuf Vohra⁴,†,
R. Ryan Meyerhoff¹,⁵,†,
Evan M. Cale⁶,†,
William E. Walkowicz⁴,†,
Nathan A. Radakovich⁶,
Kara Anasti¹,
Lawrence Armand¹,
Robert Parks¹,
Laura Sutherland¹,
Richard Scearce¹,
M. Gordon Joyce⁶,
Marie Pancera⁶,
Aliaksandr Druz⁶,
Ivelin S. Georgiev⁶,
Tarra Von Holle¹,
Amanda Eaton¹,
Christopher Fox⁷,
Steven G. Reed⁷,
Mark Louder⁶,
Robert T. Bailer⁶,
Lynn Morris⁸,⁹,
Salim S. Abdool-Karim⁸,⁹,
Myron Cohen¹⁰,
Hua-Xin Liao¹,²,‡,
David C. Montefiori¹,²,¹¹,
Peter K. Park⁴,
Alberto Fernández-Tejada⁴,
Kevin Wiehe¹,
Sampa Santra¹²,
Thomas B. Kepler¹³,
Kevin O. Saunders¹,¹¹,
Joseph Sodroski¹⁴,
Peter D. Kwong⁶,
John R. Mascola⁶,
Mattia Bonsignori¹,²,
M. Anthony Moody¹,⁵,¹⁵,
Samuel Danishefsky⁴ and
Barton F. Haynes¹,²,⁵,*,†

¹Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
²Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
³Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
⁴Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
⁵Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
⁶Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁷Infectious Disease Research Institute, Seattle, WA 98102, USA.
⁸National Institute for Communicable Diseases, Johannesburg 2131, South Africa.
⁹Center for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban 4013, South Africa.
¹⁰Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
¹¹Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
¹²Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
¹³Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.
¹⁴Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
¹⁵Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

↵*Corresponding author. Email: barton.haynes{at}dm.duke.edu (B.F.H.); munir.alam{at}dm.duke.edu (S.M.A.)

↵† These authors contributed equally to this work.
↵‡ Present address: College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

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Science Translational Medicine 15 Mar 2017:
Vol. 9, Issue 381, eaai7521
DOI: 10.1126/scitranslmed.aai7521

S. Munir Alam

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

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For correspondence: barton.haynes@dm.duke.edu munir.alam@dm.duke.edu

Baptiste Aussedat

Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Yusuf Vohra

Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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R. Ryan Meyerhoff

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

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Evan M. Cale

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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William E. Walkowicz

Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Nathan A. Radakovich

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Kara Anasti

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Lawrence Armand

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Robert Parks

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Laura Sutherland

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Richard Scearce

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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M. Gordon Joyce

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Marie Pancera

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Aliaksandr Druz

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Ivelin S. Georgiev

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Tarra Von Holle

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Amanda Eaton

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Christopher Fox

Infectious Disease Research Institute, Seattle, WA 98102, USA.

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Steven G. Reed

Infectious Disease Research Institute, Seattle, WA 98102, USA.

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Mark Louder

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Robert T. Bailer

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Lynn Morris

National Institute for Communicable Diseases, Johannesburg 2131, South Africa.Center for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban 4013, South Africa.

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Salim S. Abdool-Karim

National Institute for Communicable Diseases, Johannesburg 2131, South Africa.Center for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban 4013, South Africa.

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Myron Cohen

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Hua-Xin Liao

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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David C. Montefiori

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

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Peter K. Park

Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Alberto Fernández-Tejada

Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Kevin Wiehe

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Sampa Santra

Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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Thomas B. Kepler

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

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Kevin O. Saunders

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

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Joseph Sodroski

Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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Peter D. Kwong

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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John R. Mascola

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Mattia Bonsignori

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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M. Anthony Moody

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

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Samuel Danishefsky

Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Barton F. Haynes

Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

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For correspondence: barton.haynes@dm.duke.edu munir.alam@dm.duke.edu

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Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

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