Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

S. Munir Alam; Baptiste Aussedat; Yusuf Vohra; R. Ryan Meyerhoff; Evan M. Cale; William E. Walkowicz; Nathan A. Radakovich; Kara Anasti; Lawrence Armand; Robert Parks; Laura Sutherland; Richard Scearce; M. Gordon Joyce; Marie Pancera; Aliaksandr Druz; Ivelin S. Georgiev; Tarra Von Holle; Amanda Eaton; Christopher Fox; Steven G. Reed; Mark Louder; Robert T. Bailer; Lynn Morris; Salim S. Abdool-Karim; Myron Cohen; Hua-Xin Liao; David C. Montefiori; Peter K. Park; Alberto Fernández-Tejada; Kevin Wiehe; Sampa Santra; Thomas B. Kepler; Kevin O. Saunders; Joseph Sodroski; Peter D. Kwong; John R. Mascola; Mattia Bonsignori; M. Anthony Moody; Samuel Danishefsky; Barton F. Haynes

doi:10.1126/scitranslmed.aai7521

Research ArticleHIV

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

View ORCID ProfileS. Munir Alam¹,²,³,*,†,
View ORCID ProfileBaptiste Aussedat⁴,†,
View ORCID ProfileYusuf Vohra⁴,†,
View ORCID ProfileR. Ryan Meyerhoff¹,⁵,†,
View ORCID ProfileEvan M. Cale⁶,†,
View ORCID ProfileWilliam E. Walkowicz⁴,†,
Nathan A. Radakovich⁶,
View ORCID ProfileKara Anasti¹,
Lawrence Armand¹,
Robert Parks¹,
View ORCID ProfileLaura Sutherland¹,
Richard Scearce¹,
View ORCID ProfileM. Gordon Joyce⁶,
Marie Pancera⁶,
Aliaksandr Druz⁶,
Ivelin S. Georgiev⁶,
View ORCID ProfileTarra Von Holle¹,
View ORCID ProfileAmanda Eaton¹,
Christopher Fox⁷,
View ORCID ProfileSteven G. Reed⁷,
View ORCID ProfileMark Louder⁶,
Robert T. Bailer⁶,
View ORCID ProfileLynn Morris⁸,⁹,
View ORCID ProfileSalim S. Abdool-Karim⁸,⁹,
View ORCID ProfileMyron Cohen¹⁰,
Hua-Xin Liao¹,²,‡,
David C. Montefiori¹,²,¹¹,
Peter K. Park⁴,
View ORCID ProfileAlberto Fernández-Tejada⁴,
Kevin Wiehe¹,
Sampa Santra¹²,
View ORCID ProfileThomas B. Kepler¹³,
Kevin O. Saunders¹,¹¹,
View ORCID ProfileJoseph Sodroski¹⁴,
View ORCID ProfilePeter D. Kwong⁶,
John R. Mascola⁶,
View ORCID ProfileMattia Bonsignori¹,²,
View ORCID ProfileM. Anthony Moody¹,⁵,¹⁵,
Samuel Danishefsky⁴ and
View ORCID ProfileBarton F. Haynes¹,²,⁵,*,†

¹Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
²Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
³Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
⁴Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
⁵Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
⁶Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
⁷Infectious Disease Research Institute, Seattle, WA 98102, USA.
⁸National Institute for Communicable Diseases, Johannesburg 2131, South Africa.
⁹Center for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban 4013, South Africa.
¹⁰Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
¹¹Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
¹²Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
¹³Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.
¹⁴Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
¹⁵Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

↵*Corresponding author. Email: barton.haynes{at}dm.duke.edu (B.F.H.); munir.alam{at}dm.duke.edu (S.M.A.)

↵† These authors contributed equally to this work.
↵‡ Present address: College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

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Science Translational Medicine 15 Mar 2017:
Vol. 9, Issue 381, eaai7521
DOI: 10.1126/scitranslmed.aai7521

S. Munir Alam

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

3Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

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For correspondence: barton.haynes@dm.duke.edu munir.alam@dm.duke.edu

Baptiste Aussedat

4Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Yusuf Vohra

4Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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R. Ryan Meyerhoff

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

5Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

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Evan M. Cale

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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William E. Walkowicz

4Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Nathan A. Radakovich

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Kara Anasti

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Lawrence Armand

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Robert Parks

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Laura Sutherland

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Richard Scearce

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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M. Gordon Joyce

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Marie Pancera

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Aliaksandr Druz

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Ivelin S. Georgiev

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Tarra Von Holle

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Amanda Eaton

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Christopher Fox

7Infectious Disease Research Institute, Seattle, WA 98102, USA.

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Steven G. Reed

7Infectious Disease Research Institute, Seattle, WA 98102, USA.

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Mark Louder

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Robert T. Bailer

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Lynn Morris

8National Institute for Communicable Diseases, Johannesburg 2131, South Africa.

9Center for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban 4013, South Africa.

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Salim S. Abdool-Karim

8National Institute for Communicable Diseases, Johannesburg 2131, South Africa.

9Center for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban 4013, South Africa.

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Myron Cohen

10Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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Hua-Xin Liao

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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David C. Montefiori

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

11Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

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Peter K. Park

4Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Alberto Fernández-Tejada

4Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Kevin Wiehe

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

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Sampa Santra

12Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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Thomas B. Kepler

13Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

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Kevin O. Saunders

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

11Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.

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Joseph Sodroski

14Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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Peter D. Kwong

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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John R. Mascola

6Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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Mattia Bonsignori

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

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M. Anthony Moody

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

5Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

15Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.

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Samuel Danishefsky

4Department of Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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Barton F. Haynes

1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

2Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

5Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.

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For correspondence: barton.haynes@dm.duke.edu munir.alam@dm.duke.edu

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Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

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