Contents
15 March 2017
Vol 9, Issue 381
Vol 9, Issue 381
Focus
- Total-body imaging: Transforming the role of positron emission tomography
The first total-body positron emission tomography (TB-PET) scanner represents a radical change for experimental medicine and diagnostic health care.
Research Articles
- Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide
A synthetic glycopeptide mimics a key neutralizing epitope on the HIV-1 envelope and can be used to isolate HIV-1 broadly neutralizing antibodies.
- Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies
Identification of maturation stages of V3-glycan neutralizing antibodies explains the long duration required for their development.
- Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors
Anti-CD47 antibody is effective for treating malignant pediatric brain tumors without detectable toxicity in patient-derived xenograft models.
- A dye-assisted paper-based point-of-care assay for fast and reliable blood grouping
A paper-based assay for rapid and reliable blood grouping uses dye-based color changes as a visual readout to identify distinct blood components.
Editors' Choice
- Rounding up sickle cells with gene therapy
A report of a patient treated with ex vivo lentiviral gene transfer to hematopoietic stem cells shows the promise of gene therapy for sickle cell anemia.
- Richer data with personalized GEMs
Personalized genome-scale metabolic models augment clinical hepatic steatosis data and motivate treatment based on glutathione repletion.
- Gamete fusion gone viral
Enveloped virus infection may be linked to the origin of sexual reproduction.
- Modeling Alzheimer’s disease in mice with human neurons
Human neurons transplanted into a mouse model for Alzheimer’s disease show human-specific vulnerability to β-amyloid plaques and may help to identify new therapeutic targets.
About The Cover
ONLINE COVER A Better Blood Type Test. A paper assay using a pH indicator dye and immobilized antibodies can rapidly determine blood type (Zhang et al.). A small volume of blood placed at the center of a disc of radially-arranged test strips produced colorimetric readouts at the ends of the strips near the disc circumference. Spectroscopy (pink light on the disc in the foreground) automatically analyzed the teal or brown-colored readouts. Using uncentrifuged human blood samples, the assay detected antigens on red blood cells (forward typing) and antibodies in blood plasma (reverse typing) within 2 min for ABO, Rhesus, and rare blood types. [CREDIT: HONG ZHANG AND YANG LUO/SCIENCE TRANSLATIONAL MEDICINE]