Research ArticleVACCINATION

An oral microjet vaccination system elicits antibody production in rabbits

See allHide authors and affiliations

Science Translational Medicine  08 Mar 2017:
Vol. 9, Issue 380, eaaf6413
DOI: 10.1126/scitranslmed.aaf6413

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Time for a booster shot? Open wide instead

No one likes to be on the receiving end of a needle, which can make routine childhood vaccinations especially problematic. Aran et al. developed a needle-free drug delivery device that can be administered orally. The MucoJet device used a simple chemical reaction to deliver a jet of vaccine—in this case, ovalbumin—that penetrated the buccal mucosa when placed against the cheek inside the oral cavity in rabbits. The rabbits showed evidence of anti-ovalbumin antibodies in cheek tissue and ear vein blood draws up to 6 weeks after vaccination.